Evidence map›Paper›PMID 40232555›Full record

ArticleDiscover oncology2025

Genetic variants in m6A regulator genes confer susceptibility and progression of HCC in a Northern Chinese population.

Guohua Ji, Cize Gao, Yi Yang, Yuli Ding, Ruining Liu, Shuang Wu, Xuelong Zhang, Xiao Liang, Songbin Fu, Xiaobo Cui

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PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Guohua Ji *Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China.
Cize Gao *Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China.
Yi Yang *Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China.
Yuli DingLaboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China.
Ruining LiuLaboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China.
Shuang WuLaboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China.
Xuelong ZhangLaboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China.
Xiao LiangLaboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China.
Songbin FuLaboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China. fusb@ems.hrbmu.edu.cn.
Xiaobo CuiLaboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China. cuixiaobo@hrbmu.edu.cn.

Funding

HMU Marshal Initiative Funding No. HMUMIF-21007Natural Science Foundation of Heilongjiang Province No. LH2022H007
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality globally. While m6A regulators are implicated in cancer progression, the role of single nucleotide polymorphisms (SNPs) in m6A regulator genes in HCC susceptibility remains underexplored. Here, we evaluated 31 candidate SNPs across eight dysregulated m6A regulator genes in a case-control study comprising 800 HCC patients and 800 healthy controls from Northeast China. Genotyping revealed three SNPs significantly associated with elevated HCC risk: rs2736158 C allele (PRRC2A; adjusted odds ratio [OR] = 1.295, 95% [CI] = 1.039-1.615, p = 0.021), rs9366785 A allele (PRRC2A; adjusted odds ratio [OR] = 1.312, 95% [CI] = 1.011-1.704, p = 0.041), and rs274054 C allele (IGF2BP3; adjusted odds ratio [OR] = 1.224, 95% [CI] = 1.040-1.440, p = 0.015). Comparison of genotype frequency of three SNPs under given genetic models further linked rs274054 CC (IGF2BP3), rs2736158 CC (PRRC2A), and rs9366785 AA + AG (PRRC2A) genotypes to higher HCC risk. Subgroup analyses identified associations between specific genotypes (e.g., rs9906944 TT/TC in IGF2BP1) and adverse clinicopathological features, including vascular invasion and liver cirrhosis. Haplotype analysis highlighted the CACA haplotype (PRRC2A: rs280801, rs2736171, rs2736158, rs2736157) as a high-susceptibility marker (adjusted odds ratio [OR] = 1.297, 95% [CI] = 1.041-1.616, p = 0.020). Our findings suggest that m6A regulator SNPs contribute to HCC susceptibility and progression, offering insights into genetic biomarkers for risk stratification in Northeast Chinese populations.

Indexed as

Hepatocellular carcinomaIGF2BP1IGF2BP3M6APRRC2ASingle nucleotide polymorphism

Identifiers

PMID40232555
PMCPMC12000497

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