Evidence map›Paper›PMID 40232523›Full record

ArticleMolecular biology reports2025

Evaluation of hepatic cancer stem cells (CD

Amber Pervez, Behramand Khan, Gul Nabi Khan, Sumayya Khattak, Mazhar Ali, Komal Mujeeb, Bushra Nasib, Hyung Goo Kim, Irfan Zia Qureshi, Muhammad Arshad

Abstract read
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In one paragraph

Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Amber PervezDepartment of Zoology, Islamia College University, Peshawar, Pakistan.ORCID http://orcid.org/0009-0005-5345-2363
Behramand KhanDepartment of Chemistry, Islamia College University, Peshawar, Pakistan.ORCID http://orcid.org/0000-0002-2200-3195
Gul Nabi KhanDepartment of Zoology, Islamia College University, Peshawar, Pakistan. gulnabi@icp.edu.pk.ORCID http://orcid.org/0000-0002-8740-9815
Sumayya KhattakDepartment of Zoology, Islamia College University, Peshawar, Pakistan.ORCID http://orcid.org/0009-0005-0182-7629
Mazhar AliDepartment of Zoology, Islamia College University, Peshawar, Pakistan.ORCID http://orcid.org/0009-0002-6288-9565
Komal MujeebDepartment of Chemistry, Islamia College University, Peshawar, Pakistan.ORCID https://orcid.org/0009-0001-2127-388X
Bushra NasibInstitute of Pathology and Diagnostic Medicine, Khyber Medical University, Peshawar, Pakistan.ORCID http://orcid.org/0009-0009-3185-6091
Hyung Goo KimDepartment of Neurosurgery, Robert Wood Johnson Medical School, The State University of New Jersey, Rutgers, USA.ORCID http://orcid.org/0000-0003-4497-4686
Irfan Zia QureshiDepartment of Zoology, Quaid-i-Azam University, Islamabad, Pakistan.ORCID http://orcid.org/0000-0003-2184-5427
Muhammad ArshadBiochemistry Section, Jhang Campus, University of Veterinary and Animal Sciences, Lahore, Pakistan. muhammad.arshad@uvas.edu.pk.ORCID http://orcid.org/0000-0001-7199-0118

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancer stem cells (CSCs) play a critical role in the initiation and heterogeneity of a variety of cancers due to their pluripotent nature and capacity for asymmetric cell division. Therefore, uncovering the carcinogens that increase the CSC population in target tissues is crucial for understanding the genesis of cancer. The therapeutic potential of Operculina turpethum (OT) derived silver nanoparticles (AgNPs) was assessed in diethylnitrosamine (DEN)-induced CSC populations; CD73+, CD44+, and CD90 + of hepatic tissues in male rats.

methodsHistopathology, fluorescence-activated cell sorting (FACS), and RT-qPCR were performed on the control, DEN, DEN + AgNPs, and AgNPs-treated groups. AgNPs were characterized by FTIR, EDX, XRD, and SEM.

resultsAgNPs were confirmed by intense surface plasmon resonance at 425 nm. Antioxidants, the reducing sugars responsible for Ag

conclusionAll together, DEN-induced the hepatic CSC cell populations and the OT mediated AgNPs have therapeutic potential to attenuate the harmful effects of DEN. This study provides evidenced that OT-synthesised AgNPs may be considered as a therapeutic agent for liver related malignancies.

Indexed as

Liver NeoplasmsMetal NanoparticlesNeoplastic Stem CellsSilverAnimalsDiethylnitrosamineHyaluronan ReceptorsLiverMaleRatsThy-1 AntigensDiethylnitrosamineHyaluronan ReceptorsSilverThy-1 AntigensBiogenic silver nanoparticlesCancer stem cellsDiethylnitrosamineFlow cytometryOperculina turpethumRatRT-qPCR

Identifiers

PMID40232523

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.