Evidence map›Paper›PMID 40232382›Full record

ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2025

Reduction of the planning target volume with daily online adaptive radiotherapy in bladder cancer.

Levente Varga, Ádám Gáldi, Domonkos Szegedi, András Herein, Dóra Pulugor, István Nahaji, László Gesztesi, Kliton Jorgo, Zoltán Takácsi Nagy, Csaba Polgár and 3 more

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Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Levente VargaCenter of Radiotherapy, National Institute of Oncology, Budapest, Hungary.
Ádám GáldiCenter of Radiotherapy, National Institute of Oncology, Budapest, Hungary.
Domonkos SzegediCenter of Radiotherapy, National Institute of Oncology, Budapest, Hungary.
András HereinCenter of Radiotherapy, National Institute of Oncology, Budapest, Hungary.
Dóra PulugorFaculty of Medicine, Semmelweis University, Budapest, Hungary.
István NahajiCenter of Radiotherapy, National Institute of Oncology, Budapest, Hungary.
László GesztesiCenter of Radiotherapy, National Institute of Oncology, Budapest, Hungary.
Kliton JorgoCenter of Radiotherapy, National Institute of Oncology, Budapest, Hungary.
Zoltán Takácsi NagyCenter of Radiotherapy, National Institute of Oncology, Budapest, Hungary.
Csaba PolgárCenter of Radiotherapy, National Institute of Oncology, Budapest, Hungary.
Zsuzsa KocsisDepartment of Radiobiology and Diagnostic Onco-Cytogenetics, Centre of Radiotherapy, National Institute of Oncology, Budapest, Hungary.
Tibor MajorCenter of Radiotherapy, National Institute of Oncology, Budapest, Hungary.
Péter ÁgostonCenter of Radiotherapy, National Institute of Oncology, Budapest, Hungary. agoston.peter@oncol.hu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionExternal radiation therapy for bladder cancer requires large planning target volumes (PTVs) due to the daily anatomy of the bladder. Online adaptive radiotherapy (oART) can reduce the PTV by considering daily anatomical changes. PATIENTS AND

methodsWe performed oART in 8 patients with muscle-invasive bladder cancer between June 10, 2022, and April 14, 2023, on an Ethos linear accelerator (Varian, Palo Alto, USA). Using the 496 cone-beam computed tomography (CBCT) images of the fractions, we retrospectively compared the differences in volumetric changes between oART and image-guided and intensity-modulated radiotherapy (IGRT/IMRT). According to our local protocol, for oART, a patient-specific PTV margin was created based on the intrafractional clinical target volume (CTV) changes observed during the first three fractions.

resultsThe average duration of treatment was 14.8 min (range 7-49 min). The average volume of the PTV with oART and IGRT/IMRT was 296.8 cm

conclusionThe use of patient-specific margins in oART allows for reduction of the PTV and dose to healthy tissues while achieving equal or better target coverage.

Indexed as

Radiotherapy, Image-GuidedRadiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-AssistedUrinary Bladder NeoplasmsAgedAged, 80 and overCone-Beam Computed TomographyDose Fractionation, RadiationFemaleHumansMaleMiddle AgedRetrospective StudiesUrinary BladderArtificial intelligenceBladder cancerCone Beam CTExternal beamRe-optimization

Identifiers

PMID40232382
PMCPMC12546546

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.