Evidence map›Paper›PMID 40232377›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Amlodipine with letrozole as maintenance post-chemotherapy: targeting calcium calcineurin calmodulin pathway and aromatase inhibitor in disseminated endometrioid adenocarcinoma of the endometrium-a case report.

Mukul Arvind Gharote, Amruta Ashok Deshpande, Amogh Satchidanand Kale

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mukul Arvind GharoteMukta Cancer Clinic, MF- 70, MAGH SECTOR, Sundarban Colony, Near Deccan Petrol Pump, Bhujbhal Farm Road, New Nashik, Maharashtra, 422009, India. mukul.gharote@gmail.com.
Amruta Ashok DeshpandeMukta Cancer Clinic, MF- 70, MAGH SECTOR, Sundarban Colony, Near Deccan Petrol Pump, Bhujbhal Farm Road, New Nashik, Maharashtra, 422009, India.
Amogh Satchidanand KaleMukta Cancer Clinic, MF- 70, MAGH SECTOR, Sundarban Colony, Near Deccan Petrol Pump, Bhujbhal Farm Road, New Nashik, Maharashtra, 422009, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

World is now clinging to immune checkpoint inhibitor in almost every type of cancer. PD-1 and PD-L1 inhibitor are taking over the treatment algorithm. But cost is an issue; we have a perspective to target energy mechanism of cytotoxic T cells to modulate the representation of PD-1 receptor so as to increase immunogenicity of cytotoxic T cells. Cellular energy mechanism is largely dependent on calcium channels and pharmacological modulation of it may help in modulating response of cytotoxic T cell. We hereby present a case of endometroid adenocarcinoma of endometrium successfully treated with CCB and hormonal treatment after a short course of chemotherapy (paclitaxel 80 mg/m

Indexed as

AmlodipineAntineoplastic Combined Chemotherapy ProtocolsCarcinoma, EndometrioidEndometrial NeoplasmsLetrozoleAgedAromatase InhibitorsCalcium Channel BlockersCalmodulinFemaleHumansAmlodipineAromatase InhibitorsCalcium Channel BlockersCalmodulinLetrozoleAmlodipineCalcium calcineurin calmodulin pathwayCalcium channel blockersEndometrial adenocarcinomaEndometroid adenocarcinoma of endometriumImmunotherapy

Identifiers

PMID40232377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.