ArticleNaunyn-Schmiedeberg's archives of pharmacology2025
Effect of gamma-terpinene on the articular inflammatory response.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Unraveling the Anti-Arthritic Potential of Bioactive Compounds FromFood science & nutrition · 2026Article
- Delta-3-Carene Presented Anti-Inflammatory and Antinociceptive Properties by Modulating Leukocyte Activation in the Experimental Inflammatory Response In Vitro and In Vivo.Molecules (Basel, Switzerland) · 2026Article
- Essential Oil ofPlants (Basel, Switzerland) · 2026Review
- Chemical Composition, Analgesic, and Anti-Inflammatory Properties ofPharmaceuticals (Basel, Switzerland) · 2025Article
- Pharmacological and molecular insights into linalool-richVeterinary world · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigates the anti-inflammatory and antinociceptive effects of gamma-terpinene (GT), a monoterpene present in essential oils, in models of acute joint inflammation and pain. GT was administered orally at doses of 25, 50, 75, and 100 mg/kg. Joint inflammation was induced by an intra-articular injection of zymosan to assess joint edema, leukocyte migration, and myeloperoxidase (MPO) enzyme activity. A carrageenan-induced paw edema model was used to evaluate edema and mechanical hyperalgesia, with measurements taken via plethysmometry and Von Frey testing. Results showed that GT significantly decreased leukocyte migration, joint edema, and MPO activity in the zymosan model, indicating an anti-inflammatory effect. In the carrageenan model, GT also demonstrated a dose-dependent reduction in paw edema and mechanical hyperalgesia, highlighting its analgesic potential. These findings support that GT possesses notable anti-inflammatory and antinociceptive properties, making it a promising candidate for natural therapeutic applications in managing inflammatory joint conditions. This suggests a potential role of GT as a natural alternative to NSAIDs and glucocorticoids (GCs), reducing inflammation while minimizing side effects. Future studies should explore its clinical applicability and long-term safety.
Indexed as
Identifiers
40232375What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.