Evidence map›Paper›PMID 40232318›Full record

SynthesisLasers in medical science2025

Extracorporeal Shock Wave Therapy versus laser therapy in treating musculoskeletal disorders: a systematic review and meta-analysis.

Mariam Ismail Hassan, Marwa Shafiek Mustafa Saleh, Mariam Hesham Sallam, Hadel Hesham Elkhodary, Mazen Mohamed Sayed, Haidy Samy, Afnan Hesham Mohamed, Ahmed Said Ashour, Esraa Mohamed Mosaid, Manar Hassan Zaghloul and 4 more

Registry-linked trialAbstract readSystematic ReviewMeta-AnalysisComparative Study
In one paragraph

Synthesis in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07660523 (Effectiveness of Second-Generation Focused Extracorporeal Shockwave Therapy Combined With Ultrasonographic Assessment in Myofascial Pain Syndrome of the Neck and Shoulder), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07660523 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effectiveness of Second-Generation Focused Extracorporeal Shockwave Therapy Combined With Ultrasonographic Assessment in Myofascial Pain Syndrome of the Neck and Shoulder: A Pilot Randomized Controlled Trial

TypeinterventionalSponsorCishan Hospital, Ministry of Health and WelfareRan2026 to 2027Enrolled60ConditionsMyofascial Pain SyndromeArmsSecond-Generation Focused Extracorporeal Shockwave Therapy, Home-Based Neck Exercise Program
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mariam Ismail HassanCollege of Physical Therapy, Misr University for Science and Technology, Giza, Giza, Egypt.
Marwa Shafiek Mustafa SalehFaculty of Physical Therapy, Cairo University, Giza, Giza, Egypt.
Mariam Hesham SallamCollege of Physical Therapy, Misr University for Science and Technology, Giza, Giza, Egypt.
Hadel Hesham ElkhodaryCollege of Physical Therapy, Misr University for Science and Technology, Giza, Giza, Egypt. 95091@must.edu.eg.
Mazen Mohamed SayedCollege of Physical Therapy, Misr University for Science and Technology, Giza, Giza, Egypt. 200023915@must.edu.eg.
Haidy SamyFaculty of Physical Therapy, Modern University for Technology and Information, Cairo, Cairo, Egypt.
Afnan Hesham MohamedCollege of Physical Therapy, Misr University for Science and Technology, Giza, Giza, Egypt.
Ahmed Said AshourCollege of Physical Therapy, Misr University for Science and Technology, Giza, Giza, Egypt.
Esraa Mohamed MosaidCollege of Physical Therapy, Misr University for Science and Technology, Giza, Giza, Egypt.
Manar Hassan ZaghloulCollege of Physical Therapy, Misr University for Science and Technology, Giza, Giza, Egypt.
Esraa Ramadan ElbatheshCollege of Physical Therapy, Misr University for Science and Technology, Giza, Giza, Egypt.
Hina VaishSchool of Health Sciences, Chhatrapati Shahu Ji Maharaj University, Kanpur, Kanpur, India.
Alshehri Mohammed Abdullah ACollege of Applied Science, Physical Therapy, Taif University, Taif, Saudi Arabia.
Ahmed Ibrahim AbdelhamedCollege of Physical Therapy, Misr University for Science and Technology, Giza, Giza, Egypt. 87485@must.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This systematic review aimed to compare the effectiveness of Extracorporeal Shock Wave Therapy (ESWT) versus Laser therapy (Low-Level Laser Therapy (LLLT) and High-Intensity Laser Therapy (HILT) in treating musculoskeletal disorders (MSKDs). Systematic searches of randomized clinical trials (RCTs) were performed in six databases from inception till February 2025. Two researchers independently screened titles, abstracts, and full-text articles. Eligible studies had to report at least one of the following outcomes: pain, functionality, strength, range of motion (ROM), and quality of life (Qol). Risk of bias was assessed using the revised Cochrane Collaboration tool (RoB 2.0). Meta-analysis was conducted using Review Manager software version 5.4.1, and quality of evidence was evaluated using the GRADE approach. Twenty-eight RCTs involving 1,460 patients were included. The findings indicated that neither LLLT nor HILT showed a significant difference from ESWT in pain, strength, ROM, or quality of life. However, ESWT demonstrated a marginal statistically significant functional advantage over LLLT, but not over HILT. The GRADE certainty rating was rated as very low to moderate. According to GRDAE certainty rating, ESWT and laser therapies (LLLT and/or HILT) had equivalent effect in improving pain, strength, ROM, and Qol in patients with MSKDs, while ESWT had some short-term effects in improving functions more than LLLT but not than HILT. Large RCTs with higher methodological quality are needed to draw more incisive conclusions.

Indexed as

Extracorporeal Shockwave TherapyLaser TherapyLow-Level Light TherapyMusculoskeletal DiseasesHumansQuality of LifeRandomized Controlled Trials as TopicRange of Motion, ArticularTreatment OutcomeFunctional recoveryPain managementPhotobiomodulationRehabilitationShockwave therapySoft tissue disorders

Identifiers

PMID40232318
PMCPMC12000203

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.