Evidence map›Paper›PMID 40232217›Full record

GuidelineEndocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists2025

American Association of Clinical Endocrinology Consensus Statement on Management of Multiple Endocrine Neoplasia Type 1.

Jaydira Del Rivero, Alexandra Gangi, Justin P Annes, Sina Jasim, Jason Keller, Michelle D Lundholm, Julie M Silverstein, Tanaz M Vaghaiwalla, Robert A Wermers

Abstract readPractice Guideline
In one paragraph

Guideline in Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jaydira Del RiveroNational Institutes of Health, National Cancer Institute Center for Cancer Research, Bethesda, Maryland.
Alexandra GangiDepartment of Surgery, Division of Surgical Oncology, Cedars Sinai, Los Angeles, California.
Justin P AnnesDivision of Endocrinology, Department of Medicine, Stanford University, Stanford, California.
Sina JasimDepartment of Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri.
Jason KellerVienna, Virginia.
Michelle D LundholmDepartment of Endocrinology, Diabetes & Metabolism, Cleveland Clinic, Cleveland, Ohio.
Julie M SilversteinDepartment of Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri.
Tanaz M VaghaiwallaDivision of Endocrine Surgery, DeWitt Daughtry Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida.
Robert A WermersDivision of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Medicine, Mayo Clinic, Rochester, Minnesota.

Funding

The Role of Adenosine Kinase in Controlling Beta-Cell RegenerationR01DK101530 · NIDDK · STANFORD UNIVERSITY · PI ANNES, JUSTIN PIERCE · 2015 to 2024
$3.8M
Developing A Platform Technology For β-Cell-Targeted Drug DeliveryU01DK136965 · NIDDK · STANFORD UNIVERSITY · PI Justin Pierce Annes · 2023 to 2026
$2.0M
NIDDK NIH HHS R01 DK101530NIDDK NIH HHS U01 DK136965
6 · The paper itself

Abstract

objectiveThis document presents the findings of the American Association of Clinical Endocrinology (AACE) on the diagnosis, management, and surveillance of patients with multiple endocrine neoplasia type 1 (MEN1) and associated tumors. The task force included a diverse group of experts in endocrinology, oncology, genetics, surgery, and patient representation. A comprehensive literature review was conducted to address key issues related to the evaluation, surveillance, and treatment of MEN1-related tumors.

methodsThe task force, comprised of 9 members with expertise in endocrinology, surgery, medical oncology, genetics, and patient advocacy, collaborated to develop guidance for the evaluation, surveillance, and management of MEN1-associated tumors. Consensus was defined as ≤1 dissenting vote and significant majority as ≥75%. Relevant studies were identified through a literature review process, and consensus statements were based on the available evidence.

resultsThe task force deliberated on the surveillance, evaluation, and management of MEN1-related tumors including parathyroid, pituitary, and gastroenteropancreatic neuroendocrine tumors and other tumors of relevance. The document also addresses the indications for MEN1 genetic testing.

conclusionsThis consensus statement aims to offer evidence-informed guidance for health care providers involved in the care of patients with MEN1 and associated tumors. It provides guidance on diagnostic tools, genetic testing criteria, imaging techniques, surgical interventions, and posttreatment monitoring. The practical, patient-centered approach outlined in this document is intended to improve outcomes for individuals with MEN1 and other high-risk endocrine tumors.

Indexed as

adrenalbreast tumorcutaneous tumorduodenal neuroendocrine tumorduodenopancreatic neuroendocrine tumorependymomaleiomyomaMEN1MEN1 genetic testingmeningiomamultiple endocrine neoplasia type 1neuroendocrine tumorpancreatic neuroendocrine tumorparathyroidparathyroid adenomapituitarypituitary neuroendocrine tumorthoracic neuroendocrine tumor

Identifiers

PMID40232217
PMCPMC12507346

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.