Evidence map›Paper›PMID 40232211›Full record

ArticleJACC. Basic to translational science2025

Transvalvular Mechanical Circulatory Support Reverse Remodels the Ischemic Chronic Failing Heart in an Ovine Model.

Bart Meyns, Randi J Parks, Erik Verbeken, Manon van Hecke, Steven Jacobs, Magdalena Sikole, Charlotte Van Edom, Eveline Bennek Schoepping, Piet Claus

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bart MeynsDepartment Cardiac Surgery, KULeuven, Leuven, Belgium. Electronic address: Bart.meyns@uzleuven.be.
Randi J ParksAcademic and Pre-Clinical Research, Abiomed, Inc, Aachen, Germany.
Erik VerbekenDepartment of Pathology, KULeuven, Leuven, Belgium.
Manon van HeckeDepartment of Pathology, KULeuven, Leuven, Belgium.
Steven JacobsDepartment Cardiac Surgery, KULeuven, Leuven, Belgium.
Magdalena SikoleDepartment Cardiac Surgery, KULeuven, Leuven, Belgium.
Charlotte Van EdomDepartment of Cardiovascular Sciences, KULeuven, Leuven, Belgium.
Eveline Bennek SchoeppingAcademic and Pre-Clinical Research, Abiomed, Inc, Aachen, Germany.
Piet ClausDepartment of Cardiovascular Imaging, KULeuven, Leuven, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sixteen sheep with ischemic chronic heart failure were randomized to either 3 months of Impella 5.5 support (Abiomed) or sham. Myocardial reverse remodeling by Impella support was shown by a significant reduction of end-diastolic volume (Impella 22% reduction, and control 5% increase; P = 0.011) and end-systolic volume (Impella 20% reduction, and control 11% increase; P = 0.011). Functional measurements demonstrated improved regional ejection fraction and wall thickening in the viable myocardium of hearts supported with Impella. Supported animals had a significant decrease in wall volume, with less cardiomyocyte hypertrophy than control subjects.

Indexed as

chronic heart failuremechanical circulatory supportMRImyocardial infarctionovinereverse remodeling

Identifiers

PMID40232211
PMCPMC12434274

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.