Evidence map›Paper›PMID 40232012›Full record

ArticleJournal of cosmetic dermatology2025

The Pomegranate Flower Water Extract Negatively Regulates Melanogenesis by Suppressing MITF Expression and Its Target Enzymes.

Peng Shu, Nannan Xu, Nuermaimaiti Abudukelimu, Parida Aiziti, Deng Zang, Jiangyu Zhao, Yuan Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Peng ShuHBN Research Institute and Biological Laboratory, Shenzhen Hujia Technology Co., Ltd., Shenzhen, China.ORCID https://orcid.org/0009-0004-6354-8716
Nannan XuState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, P.R. China.
Nuermaimaiti AbudukelimuState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, P.R. China.
Parida AizitiState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, P.R. China.
Deng ZangState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, P.R. China.
Jiangyu ZhaoState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, P.R. China.
Yuan WangHBN Research Institute and Biological Laboratory, Shenzhen Hujia Technology Co., Ltd., Shenzhen, China.

Funding

Xinjiang Science and Technology Major Project 2022A03018
6 · The paper itself

Abstract

backgroundThe aesthetic issues caused by pigmentation are increasing people's demand for skin whitening. Considering its long-term use, it is very important for searching safe and effective agents. Pomegranate flower, a kind of traditional Chinese medicine, has shown promising anti-inflammatory, antioxidant, and antidiabetic properties, but its potential skin-lightening effects have not been well explored.

aimsWe investigated the effect of pomegranate flower water extract (PFE) on skin lightening and elucidated its underlying mechanisms.

methodsThe radical scavenging capacity was measured by ABTS and DPPH assays, and the mechanism of lightening was detected by Western blot.

resultsPFE could obviously inhibit tyrosinase activity, which its inhibition IC

conclusionPomegranate flower extract possessed a strong antimelanogenesis effect, which resulted from inhibiting the expression of MITF and its downstream target enzymes involved in melanin synthesis. These findings provide a strong scientific basis for the use of PFE as a safe and effective skin-lightening ingredient in the cosmetic industry.

Indexed as

MelaninsMicrophthalmia-Associated Transcription FactorPlant ExtractsPomegranateSkin Lightening PreparationsAnimalsCell Line, TumorDown-RegulationFlowersMelanogenesisMiceMonophenol MonooxygenaseOxidoreductasesPyronesSkin Pigmentationkojic acidMelaninsMicrophthalmia-Associated Transcription FactorMitf protein, mouseMonophenol MonooxygenaseOxidoreductasesPlant ExtractsPyronesSkin Lightening Preparationsantimelanogenesiscosmeticmelaninpomegranate flower water extracttyrosinase activity

Identifiers

PMID40232012
PMCPMC11998895

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.