SynthesisBJS open2025
Venous thromboembolism risk in the postoperative interval during the COVID-19 pandemic: meta-analysis.
Synthesis in BJS open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Article
- Simultaneous Pneumothorax and Pulmonary Embolism With Concurrent COVID-19 After Shoulder Arthroscopy: A Case Report.Cureus · 2025Article
- Risk of perioperative mortality and venous thromboembolism after total hip or knee arthroplasty with recent COVID-19 infection: an observational study from the Kaiser Permanente Northern California Database.Acta orthopaedica · 2025Observational
- Increased Anticoagulant Requirement in Total Hip Replacement Patients Post-COVID: A Comparative Study in the Indian Population.Journal of orthopaedic case reports · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring the COVID-19 pandemic, global trends emerged, indicating increased venous thromboembolism (VTE) incidence among postoperative patients, potentially attributable to perioperative COVID-19 infection. However, there are insufficient data on VTE incidence among postoperative patients in the context of the pandemic. The aim of this study was to examine the global incidence of postoperative VTE during the COVID-19 pandemic.
methodsA systematic search of MEDLINE and Embase databases, as well as three other registered databases, was conducted from 1 January 2019 to 3 November 2023, with pre-registration in PROSPERO, the international prospective register of systematic reviews (CRD42023460464). Any study reporting patients aged ≥18 years undergoing surgery during the COVID-19 pandemic was included. Outcomes were aggregated absolute and unadjusted relative risks, plus incidence rates per 1000 person-years, of 30- or 90-day postoperative VTE in patients operated on before or during the COVID-19 pandemic and those with or without perioperative COVID-19 infection during the pandemic.
resultsOf 5943 studies, 17 were available for meta-analysis, reporting on 3 035 037 patients. VTE incidence rates in perioperative COVID-19-positive compared with COVID-19-negative patients were significantly higher after total joint arthroplasty (244 (95% c.i. 110 to 541) versus 71 (95% c.i. 47 to 108) per 1000 person-years), other orthopaedic surgery (253 (95% c.i. 240 to 266) versus 138 (95% c.i. 84 to 229) per 1000 person-years), and emergency general and gastrointestinal surgery (474 (95% c.i. 226 to 995) versus 97 (95% c.i. 61 to 157) per 1000 person-years). No significant differences in VTE rates were reported in studies comparing pre-pandemic and pandemic VTE incidence rates.
conclusionThere were consistent increased VTE rates in perioperative COVID-19-positive patients, particularly those undergoing orthopaedic surgery, and emergency general and gastrointestinal surgery. Further investigation is required to delineate postoperative VTE risk and how it varies by COVID-19 variant and vaccination to inform future practice.
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