ArticleJournal of virology2025
Extended analyses of rotavirus C (RVC) G-types and P-types reveal new cut-off value for the G-types and reclassification of strains.
Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Genetic Diversity and Evolution of Porcine Rotavirus Species A in Guangxi Province, Southern China, Between 2022 and 2025.Animals : an open access journal from MDPI · 2026Article
- High genetic diversity of porcine rotavirus A, B, and C in Hungary with putative novel VP4 genotypes.BMC veterinary research · 2026Article
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3 authors.
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Abstract
Rotavirus C (RVC) is an important cause of gastroenteritis in humans and pigs and has also been detected in cattle, ferrets, minks, and dogs. Incidental zoonotic transmissions have been described. In contrast to rotavirus A (RVA), a complete genotyping system for RVC has not yet been established due to limited or incomplete sequence data. In this study, 138 complete nucleotide sequences for VP7 (G-type) and 97 complete nucleotide sequences for VP4 (P-type) of porcine RVC-positive samples have successfully been generated and genotyped. Together with available sequences from the NCBI database, phylogenetic analyses were conducted, cut-off values were re-evaluated, and the current classification system was adapted. Pairwise identity frequency analyses revealed a new cut-off value of 82% instead of the previous 85% for the G-type and confirmed the current cut-off value of 85% for the P-type. This resulted in the identification of 21 G-types and 39 P-types, including 4 new G-types and 10 new P-types. The results of the investigations expand the existing knowledge about the genetics of RVC and demonstrate the enormous diversity of porcine RVC sequences in particular.IMPORTANCEThis article provides a new sequence data set of porcine rotavirus C (RVC) strains. The extended full-length analysis of RVC G-types and P-types enabled us to review the current classification system. According to the guidelines of the rotavirus classification working group (RCWG), the results led to a new cut-off value of RVC G-types and required the reclassification of numerous RVC G-types. In addition, several new genotypes have been found. The present work closes the aforementioned knowledge gap and provides important, comprehensive data for RVC genetic diversity.
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