SynthesisInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2025
Gestational diabetes mellitus and vascular malperfusion lesions in the placenta: A systematic review and meta-analysis.
Synthesis in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gestational diabetes mellitus and vascular malperfusion lesions in the placenta: A systematic review and meta-analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Pooled it
- Placental Pathophysiology and Developmental Programming of Adult Cardiometabolic Risk: A Narrative Review of Pregnancy Exposures.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Review
- Reduced fetal MAPSE and TAPSE in gestational diabetes mellitus: a prospective case-control study.Irish journal of medical science · 2026Article
- Placental basal plate with attached myofibers and adverse pregnancy outcomes: A systematic scoping review.Acta obstetricia et gynecologica Scandinavica · 2026Article
- The Impact of Maternal Obesity and Diabetes on the Development of Congenital Heart Defects (CHDs) in Offspring: A Narrative Review.Metabolites · 2026Review
- Placental syncytial knots in the spectrum of maternal vascular malperfusion: mechanisms and clinical implications.Vascular biology (Bristol, England) · 2026Article
- Clinical Association of Delayed Villous Maturation in Gestational Diabetes Mellitus Pregnancy: A Prospective Study.Iranian journal of pathology · 2026Article
- Gestational Diabetes Mellitus: The Dual Risk of Small and Large for Gestational Age: A Narrative Review.Medical sciences (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundGestational diabetes mellitus (GDM) can result in increased placental lesions related to high maternal blood glucose, but these relationships are not well understood.
objectiveTo examine the relationship between GDM and placental vascular malperfusion lesions: accelerated villous maturation, increased syncytial knots, delayed villous maturation, and increased fibrin deposition. SEARCH STRATEGY: PubMed, BIOSIS, and Web of Science databases were systematically searched for full-text articles in English from inception until August 21, 2024. SELECTION CRITERIA: Our inclusion criteria were randomized controlled trials, case-control, cohort, and cross-sectional studies that examined the relationship between GDM and selected placental vascular malperfusion lesions. The outcome must have been reported as a total proportion. DATA COLLECTION AND ANALYSIS: We included all eligible studies in narrative synthesis. If an outcome of interest was in at least three studies, we calculated the odds ratios (ORs) by GDM diagnosis, with 95% confidence intervals (CIs), using mixed-effects logistic regression with random study effects. We evaluated the risk of bias with the Newcastle-Ottawa Scale. MAIN
resultsWe screened 151 studies, of which eight were included (n = 1291), and six met the criteria for meta-analysis (n = 561). Unadjusted odds (95% CI) of delayed villous maturation were six-fold higher (OR: 6.37 [3.28-12.37]) in pregnancies with GDM than in those without GDM. The narrative synthesis of the literature found higher proportions of increased syncytial knots, delayed villous maturation, and increased fibrin deposition, but not accelerated villous maturation, in pregnancies with versus without GDM.
conclusionsGDM was associated with a higher risk of three placental malperfusion lesions, although there is a small number of studies in this area. Future investigations should examine if these vascular malperfusions are associated with adverse pregnancy outcomes often linked with GDM.
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