Evidence map›Paper›PMID 40231721›Full record

ArticleeLife2025

Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa.

Hyun Beom Song, Laura Campello, Anupam Mondal, Holly Y Chen, Milton A English, Michael Glen, Phillip Vanlandingham, Rafal Farjo, Anand Swaroop

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hyun Beom Song *Neurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, United States.ORCID https://orcid.org/0000-0002-3500-2984
Laura Campello *Neurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, United States.ORCID https://orcid.org/0000-0002-0869-1315
Anupam Mondal *Neurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, United States.ORCID https://orcid.org/0000-0002-3572-6392
Holly Y ChenNeurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, United States.ORCID https://orcid.org/0000-0001-8320-6714
Milton A EnglishNeurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, United States.
Michael GlenNeurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, United States.
Phillip VanlandinghamEyeCRO, Oklahoma City, United States.ORCID https://orcid.org/0000-0003-1884-6525
Rafal FarjoEyeCRO, Oklahoma City, United States.
Anand SwaroopNeurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, United States.ORCID https://orcid.org/0000-0002-1975-1141

Funding

Regulation of gene expression in the retinaZ01EY000450 · NEI · NATIONAL EYE INSTITUTE · PI SWAROOP, ANAND · 2008 to 2008
$2.4M
Intramural NIH HHS Z01 EY000450NEI NIH HHS Z01EY000450NEI NIH HHS Z01EY000546
6 · The paper itself

Abstract

Inherited retinal degenerations (IRDs) constitute a group of clinically and genetically diverse vision-impairing disorders. Retinitis pigmentosa (RP), the most common form of IRD, is characterized by gradual dysfunction and degeneration of rod photoreceptors, followed by the loss of cone photoreceptors. Recently, we identified reserpine as a lead molecule for maintaining rod survival in mouse and human retinal organoids as well as in the

Indexed as

ReserpineRetinitis PigmentosaRhodopsinAnimalsDisease Models, AnimalFemaleMaleRatsRetinal Rod Photoreceptor CellsSex FactorsReserpineRhodopsinmedicineneuroprotectionratretinal degenerationretinitis pigmentosarhodopsin mutationsmall molecule drug

Identifiers

PMID40231721
PMCPMC11999695

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.