ArticleJournal of feline medicine and surgery2025
Evaluation of urinary kidney injury molecule-1 in cats with chronic kidney disease.
Article in Journal of feline medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Increased serum amyloid A and urinary kidney injury marker-1 concentrations in cats with pyelonephritis: a diagnostic accuracy study.The Journal of small animal practice · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ObjectivesKidney injury molecule 1 (KIM-1) is a transmembrane glycoprotein on proximal renal tubular epithelial cells that is increased in the urine of cats with acute kidney injury. The utility of measuring urine KIM-1 in cats with chronic kidney disease (CKD) and the relationship with International Renal Interest Society (IRIS) stage are unknown. The objectives of this study were to determine the distribution of KIM-1 concentrations in cats with different stages of CKD and investigate the relationship between urine KIM-1 and urine specific gravity (USG), urine protein and serum urea, creatinine, phosphorus, potassium and symmetric dimethylarginine concentrations.MethodsA total of 74 cats with CKD were recruited prospectively from a first-opinion feline-only practice. Blood and urine samples were collected from all cats. The stage of CKD was determined as per IRIS guidelines. Urine KIM-1 concentration was determined with a previously validated lateral flow assay. KIM-1 was reported as a test:control ratio. The distribution of KIM-1 values in cats with CKD was determined, and the correlation between KIM-1 and other determinants of renal function was calculated. Urine KIM-1 was normalized to a USG of 1.035 and the analysis was repeated.ResultsCats with CKD had a median urine KIM-1 value of 0.1544 (range 0.038-0.540). The median KIM-1 values in cats with IRIS stage 1, 2, 3 and 4 CKD were 0.152 (range 0.113-0.512), 0.165 (range 0.038-0.540), 0.150 (range 0.037-0.448) and 0.140 (range 0.067-0.448), respectively. There were no differences in urine KIM-1 values relative to IRIS stage. Urine KIM-1 values were correlated with USG (
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