ReviewCurrent topics in medicinal chemistry2025
An Insight into the Recent Advancement in Anti-Alzheimer's Potential of Indole Derivatives and their SAR Study.
Review in Current topics in medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Recent trends in anti-Alzheimer's potential of novel biologically active isatin analogues: synthetic strategies, structural activity relationship studies and molecular docking insights.Molecular diversity · 2026Review
- The Selectivity of Butyrylcholinesterase Inhibitors Revisited.Molecules (Basel, Switzerland) · 2025Review
- Exploring Indole-Based Molecules as Novel Therapeutics for Parkinson's Disease: A Comprehensive Review.Mini reviews in medicinal chemistry · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer is a progressive neurodegenerative disease characterized by change in brain that led to the buildup of specific proteins, ultimately causing brain shrinkage and the death of brain cells. It is the leading cause of dementia, manifesting as a gradual decline in memory, cognitive abilities, behavior, and social functioning, which severely impairs a person's ability to carry out daily activities. The complexity of Alzheimer's poses significant challenges to modern medicine, making the development of new therapeutic strategies crucial. Indole derivatives, with their broad spectrum of pharmacological activities, have garnered attention for their potential in treating Alzheimer's disease. This review provides a detailed summary of recent progress in developing indole derivatives as therapeutic agents for Alzheimer's disease. It thoroughly examines the pharmacological properties of various indole derivatives, including their mechanisms of action. These compounds have been shown to influence several processes, such as amyloid-beta aggregation, MAO inhibition, AChE and BuChE inhibition. Furthermore, this review discusses the structural modifications of indole derivatives designed to improve their therapeutic effectiveness.
Indexed as
Identifiers
40231514What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.