Evidence map›Paper›PMID 40231481›Full record

ArticleJournal of the American Chemical Society2025

Hydrodealkenylative C(sp

Jeremy H Dworkin, Zhuoxi M Chen, Kathleen C Cheasty, Aris V Rubio, Ohyun Kwon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Synthesis through C(spAccounts of chemical research · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jeremy H DworkinDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.
Zhuoxi M ChenDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.
Kathleen C CheastyDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.
Aris V RubioDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.
Ohyun KwonDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.ORCID 0000-0002-5405-3971

Funding

Deconstructive Molecular Editing Technology Involving C-C Bond ScissionR01GM141327 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KWON, OHYUN · 2021 to 2024
$1.4M
800 MHz NMR Console and Cryoprobe ReplacementS10OD025073 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEIGON, JULI · 2018 to 2018
$1.1M
NIGMS NIH HHS R01 GM141327NIH HHS S10 OD025073
6 · The paper itself

Abstract

Advancements in radical capture strategies have expanded the range of products accessible from alkenes through dealkenylative synthesis. These methods, however, are still limited, as they rely on ozonolysis to generate the key peroxide intermediates from alkenes. Ozonolysis has several limitations. It is not compatible with alkenes containing electron-rich aromatics. It is also inapplicable to certain alkene substitution patterns in the context of dealkenylative synthesis. Additionally, it struggles with sterically hindered alkenes, internal nucleophiles and electrophiles, and allylic alcohols. In this paper, using Isayama-Mukaiyama peroxidation (IMP), we address the limitations of ozonolysis to rescue previously inaccessible alkene substrates and broaden the applicability of dealkenylative functionalization. In particular, we apply IMP in hydrodealkenylation and describe a novel radical hydrogenation condition─employing catalytic [Fe

Identifiers

PMID40231481
PMCPMC12077574

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.