Evidence map›Paper›PMID 40231449›Full record

ArticleEmerging microbes & infections2025

Identification of host genetic factors modulating β-lactam resistance in

Hyunhee Kim, Travis Bell, Kihyun Lee, Jeongyun Jeong, James C A Bardwell, Changhan Lee

Abstract read
In one paragraph

Article in Emerging microbes & infections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hyunhee KimDepartment of Biological Sciences, Ajou University, Suwon, South Korea.
Travis BellDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Kihyun LeeCJ Bioscience, Seoul, South Korea.
Jeongyun JeongDepartment of Biological Sciences, Ajou University, Suwon, South Korea.
James C A BardwellDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Changhan LeeDepartment of Biological Sciences, Ajou University, Suwon, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since β-lactam antibiotics are widely used, emergence of bacteria with resistance to them poses a significant threat to society. In particular, acquisition of genes encoding β-lactamase, an enzyme that degrades β-lactam antibiotics, has been a major contributing factor in the emergence of bacteria that are resistant to β-lactam antibiotics. However, relatively few genetic targets for killing these resistant bacteria have been identified to date. Here, we used a systematic approach called transposon-sequencing (Tn-Seq), to screen the

Indexed as

beta-Lactamasesbeta-Lactam ResistanceDNA Transposable ElementsEscherichia coliPlasmidsAmpicillinAnti-Bacterial Agentsbeta-LactamsEscherichia coli ProteinsHumansMicrobial Sensitivity TestsMutationAmpicillinAnti-Bacterial Agentsbeta-Lactamasesbeta-LactamsDNA Transposable ElementsEscherichia coli ProteinsEscherichia coligshAphoPQPseudomonas aeruginosaskpypfNβ-lactamase producing bacteriaβ-lactam resistance

Identifiers

PMID40231449
PMCPMC12024506

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.