A systematic review of tumour position reproducibility and stability in breath-hold for radiation therapy of the upper abdomen.

Background and purpose: Upper abdominal malignancies are relatively rare, and although surgery is considered the primary treatment option, radiation therapy has an emerging role in the management of liver, pancreas, kidney and adrenal gland tumours. Furthermore, stereotactic radiation therapy for the management of upper abdominal metastases is an expanding clinical indication. Breath-hold is one respiratory motion management strategy used in upper abdominal radiation therapy, and the reproducibility, and stability of breath-hold is critical for overall treatment accuracy. Materials and methods: A systematic review of the literature was conducted in Medline, Embase and Cochrane databases with keyword and vocabulary terms related to radiation therapy, breath-hold and upper abdominal tumours. Results: Following screening against the selection criteria, 41 studies were included. Breath-hold reproducibility was the most commonly reported outcome and exhale breath-hold was the most common type. Studies were either prospective or retrospective cohort studies, and the mean sample size was 19 participants. The risk of bias of each included study was assessed, and the mean quality assessment score for included studies was 90 % (77-100 %). Median exhale breath-hold cranio-caudal inter-fraction reproducibility was 0.6 mm, (IQR 0.3-1.6 mm), compared to inspiratory breath-hold 0.0 mm (IQR -0.6-2.97 mm). Stability measurements were ≤3 mm in 71 % of studies, irrespective of breath-hold type. Discussion: Formulating institutional protocols for best clinical practice regarding breath-hold for upper abdominal tumours is challenging, given the significant variation in practices, interventions and definitions observed in the literature. Further investigation to individualise breath-hold strategies and safety margins is warranted.