Evidence map›Paper›PMID 40231223›Full record

ArticlePhysics and imaging in radiation oncology2025

Investigation of changes in planning target volume and regression probability of rectal boost using in-silico cone-beam computed tomography-guided online-adaptive radiotherapy.

Julien Pierrard, David Dechambre, Geneviève Van Ooteghem

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physics and imaging in radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Julien PierrardUCLouvain, Institut de Recherche Experimentale et Clinique (IREC), Center of Molecular Imaging, Radiotherapy and Oncology (MIRO), Brussels, Belgium.
David DechambreDepartment of Radiation Oncology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
Geneviève Van OoteghemUCLouvain, Institut de Recherche Experimentale et Clinique (IREC), Center of Molecular Imaging, Radiotherapy and Oncology (MIRO), Brussels, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: Radiotherapy boost to the primary tumour may enable organ preservation in locally advanced rectal cancer (LARC). This study evaluated cone-beam computed tomography (CBCT)-guided online-adaptive radiotherapy (ART) to reduce rectal boost planning target volume (PTV Materials and methods: Eleven LARC patients were included in this Results: PTV Conclusions: Online-ART significantly reduce rectal boost PTV margin. It allows better target volume coverage with a similar risk of radiation-induced toxicities, even when escalating the dose. Therefore, online-ART should be considered to perform dose-escalation in LARC patients with the objective of organ preservation.

Indexed as

Adaptive radiotherapyDose escalationPTV marginRectal boostRectum radiotherapy

Identifiers

PMID40231223
PMCPMC11994390

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.