Evidence map›Paper›PMID 40231206›Full record

ReviewBiomaterials research2025

Nanomaterial-Based Autophagy Modulation: Multiple Weapons to Inflame Immune Systems and the Tumor Microenvironment.

Min Jiang, Xinyi Zhang, Zhilei Cui, Meng Li, Huifen Qiang, Keqin Ji, Meigui Li, Xinyang Xuan Yuan, Beibei Wen, Qian Xue and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomaterials research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Min JiangDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China.
Xinyi ZhangChanghai Clinical Research Unit, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China.
Zhilei CuiDepartment of Respiratory Medicine, XinHua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Meng LiDepartment of Dermatology, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.
Huifen QiangChanghai Clinical Research Unit, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China.
Keqin JiChanghai Clinical Research Unit, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China.
Meigui LiSchool of Pharmacy, Henan University, Kaifeng 475004, China.
Xinyang Xuan YuanDepartment of Dermatology, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China.
Beibei WenSchool of Pharmacy, Henan University, Kaifeng 475004, China.
Qian XueChanghai Clinical Research Unit, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China.
Jie GaoChanghai Clinical Research Unit, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China.
Zhengmao LuDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China.
Yan WuCollege of Life Science, Mudanjiang Medical University, Mudanjiang 157011, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagy, a fundamental cellular process, is a sensitive indicator of environmental shifts and is crucial for the clearance of cellular debris, the remodeling of cellular architecture, and the facilitation of cell growth and development. The interplay between stromal, tumor, and immune cells within the tumor microenvironment is intricately linked to autophagy. Therefore, the modulation of autophagy in these cell types is essential for developing effective cancer treatment strategies. This review describes the design and optimization of nanomaterials that modulate autophagy in tumor-associated and immune cells. This review elucidates the primary mechanisms by which nanomaterials induce autophagy and discusses their application in cancer therapy, underscoring the potential of these materials to eradicate cancer cells, bolster the immune response, and elicit robust, enduring antitumor immunity, thereby advancing the frontiers of oncological treatment.

Identifiers

PMID40231206
PMCPMC11994884

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.