ReviewJournal of clinical and experimental dentistry2025
Is periodontitis a risk factor for ischemic stroke?: Systematic review and meta-analysis.
Review in Journal of clinical and experimental dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Periodontitis and risk of stroke: a systematic review and meta-analysis of observational studies.Frontiers in neurology · 2025Pooled it
- Periodontitis and Stroke Onset, Medical Costs and Length of Hospital Stay: A 5-Year Cohort Study.Journal of clinical periodontology · 2026Article
- Periodontitis, colorectal cancer and associated factors: A cross-sectional study.Journal of clinical and experimental dentistry · 2026Review
- A Review on the Role of Oral Bacteria in Stroke.International journal of molecular sciences · 2025Review
- Periodontitis associated with prostate cancer and other urological cancers in patients over 50 years of age: a cross-sectional study.Medicina oral, patologia oral y cirugia bucal · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Evidence suggests an association between periodontitis and ischemic stroke due to the elevated production of inflammatory markers and damage by infectious agents, which would promote a recurrent prothrombotic state. Therefore, the present systematic review and meta-analysis were carried out to determine whether periodontitis is a risk factor for ischemic stroke. Material and Methods: A systematic search was conducted in five databases, including cohort and case-control studies published up to April 2024, in which periodontitis was evaluated as a risk factor for ischemic stroke through relative risk (RR), hazard ratio (HR) and odds ratio (OR). The Newcastle-Ottawa Scale (NOS) was used to assess the risk of bias, and the GRADE system was used to determine the certainty of the evidence. Results: Of the 1121 studies found, 16 were included in the qualitative analysis, and 10 were meta-analyzed. The global synthesis showed that periodontitis was a risk factor for ischemic stroke (OR=2.59, I2=96%), with the same result being found for the case-control subgroup (OR=3.44, I²=73%) and the cohort subgroup (OR=2.05, I²=99%). Individuals with periodontitis were also found to be more likely to develop lacunar infarcts (OR=5.00, I2=0%). Conclusions: Periodontitis is a risk factor for ischemic stroke with very low certainty of evidence and high heterogeneity. Furthermore, individuals with periodontitis were more likely to develop lacunar infarcts, with moderate certainty of evidence and null heterogeneity.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.