Evidence map›Paper›PMID 40231103›Full record

ArticleHeart rhythm O22025

Impact of atrial functional substrate in patients with atrial fibrillation: The potential utility of decremental evoked potential mapping in the atrium.

Yasuhito Kotake, Fumiyasu Hirano, Shunsuke Kawatani, Aiko Takami, Takuya Tomomori, Akihiro Okamura, Masaru Kato, Kazuhiro Yamamoto

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In one paragraph

Article in Heart rhythm O2, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yasuhito KotakeDepartment of Cardiovascular Medicine, Endocrinology and Metabolism, Faculty of Medicine, Tottori University, Yonago, Japan.
Fumiyasu HiranoDepartment of Cardiovascular Medicine, Endocrinology and Metabolism, Faculty of Medicine, Tottori University, Yonago, Japan.
Shunsuke KawataniDepartment of Cardiovascular Medicine, Endocrinology and Metabolism, Faculty of Medicine, Tottori University, Yonago, Japan.
Aiko TakamiDepartment of Cardiology, Tottori Prefectural Central Hospital, Tottori, Japan.
Takuya TomomoriDepartment of Cardiovascular Medicine, Endocrinology and Metabolism, Faculty of Medicine, Tottori University, Yonago, Japan.
Akihiro OkamuraDepartment of Cardiovascular Medicine, Endocrinology and Metabolism, Faculty of Medicine, Tottori University, Yonago, Japan.
Masaru KatoDepartment of Cardiovascular Medicine, Endocrinology and Metabolism, Faculty of Medicine, Tottori University, Yonago, Japan.
Kazuhiro YamamotoDepartment of Cardiovascular Medicine, Endocrinology and Metabolism, Faculty of Medicine, Tottori University, Yonago, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Decremental evoked potential (DEEP) is one of the functional substrates mainly used in the field of ventricular arrhythmias, which is suggested to be a critical target of reentrant ventricular tachycardia. Objective: The purpose of this study is to investigate the characteristics of patients with atrial functional substrates expressed by DEEP and their clinical significance. Methods: Patients presenting for atrial fibrillation (AF) ablation from April 2023 to March 2024 at Tottori University Hospital were analyzed. After cryoballoon pulmonary vein isolation, DEEP was evaluated at the left atrial roof and posterior wall by extrastimulus pacing maneuvers. To verify the clinical significance of atrial DEEP, the relationship between atrial DEEP and various clinical valuables including the pericardial fat volume and clinical outcomes was assessed. Results: A total of 102 patients were included and 45% had persistent AF. Fifty-three percent of patients exhibited DEEP properties. DEEP was more prevalent in patients with persistent AF (61% vs 39%, Conclusion: This study demonstrated a correlation between atrial DEEP and longer duration of AF, higher brain natriuretic peptide levels, greater pericardial fat volume, and more early AF recurrence, suggesting that DEEP reflects a certain aspect of atrial electrophysiological remodeling and is a potential ablation target for AF.

Indexed as

Atrial fibrillationDecremental evoked potentialElectrophysiological remodelingFunctional substratePericardial fat volume

Identifiers

PMID40231103
PMCPMC11993794

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.