Evidence map›Paper›PMID 40231089›Full record

ArticleHeart rhythm O22025

Asthma and the risk of cardiac events among patients with long QT syndrome after age 40.

Alon Barsheshet, Ilan Goldenberg, Kirill Buturlin, Aharon Erez, Gustavo Goldenberg, Itamar Zahavi, Bronislava Polonsky, Scott McNitt, Mehmet Aktas, Wojciech Zareba and 1 more

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Article in Heart rhythm O2, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Alon BarsheshetDepartment of Cardiology, Rabin Medical Center, Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel.
Ilan GoldenbergClinical Cardiovascular Research Center, University of Rochester Medical Center, Rochester, New York.
Kirill ButurlinDepartment of Cardiology, Rabin Medical Center, Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel.
Aharon ErezDepartment of Cardiology, Rabin Medical Center, Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel.
Gustavo GoldenbergClinical Cardiovascular Research Center, University of Rochester Medical Center, Rochester, New York.
Itamar ZahaviClinical Cardiovascular Research Center, University of Rochester Medical Center, Rochester, New York.
Bronislava PolonskyClinical Cardiovascular Research Center, University of Rochester Medical Center, Rochester, New York.
Scott McNittClinical Cardiovascular Research Center, University of Rochester Medical Center, Rochester, New York.
Mehmet AktasClinical Cardiovascular Research Center, University of Rochester Medical Center, Rochester, New York.
Wojciech ZarebaClinical Cardiovascular Research Center, University of Rochester Medical Center, Rochester, New York.
Gregory GolovchinerDepartment of Cardiology, Rabin Medical Center, Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Limited data exist on the impact of asthma on long QT syndrome (LQTS) in middle-aged and older adults. Objective: This study aimed to examine the association between asthma, β2-agonist treatment, and cardiac events (CEs) in LQTS patients over 40 years of age. Methods: The risk of CEs (comprising syncope, aborted cardiac arrest, implantable cardioverter-defibrillator shock, or sudden cardiac death) from age 40 through 75 years, by the presence of asthma with and without treatment with a β2-agonist inhaler, was assessed among 1020 LQTS patients from the Rochester LQTS Registry. Results: Among 1020 LQTS patients, 162 (16%) had asthma by age 40 years or subsequent follow-up, with 63% treated with a β2-agonist inhaler. Patients with asthma vs no asthma had a higher cumulative rate of CEs from age 40 through 75 years (44% vs 26%, Conclusion: The presence of asthma is associated with increased risk of CEs among middle-aged and older patients with LQTS regardless of baseline risk factors or treatment with a β2-agonist inhaler.

Indexed as

AsthmaImplantable cardioverter-defibrillatorLong QT syndromeSudden cardiac deathSyncope

Identifiers

PMID40231089
PMCPMC11993786

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.