Evidence map›Paper›PMID 40231069›Full record

ArticlePeerJ2025

Circulating microRNAs demonstrate limited diagnostic potential for diabetic retinopathy in the population of Kazakhstan.

Aizhan Magazova, Yeldar Ashirbekov, Arman Abaildayev, Kantemir Satken, Gulzhakhan Utegenova, Ayaz Belkozhayev, Altynay Balmukhanova, Zaure Dzhumatayeva, Ainagul Beissova, Iryna Shargorodska and 2 more

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Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Aizhan MagazovaAitkhozhin Institute of Molecular Biology and Biochemistry, Almaty, Kazakhstan.
Yeldar AshirbekovAitkhozhin Institute of Molecular Biology and Biochemistry, Almaty, Kazakhstan.
Arman AbaildayevAitkhozhin Institute of Molecular Biology and Biochemistry, Almaty, Kazakhstan.
Kantemir SatkenAitkhozhin Institute of Molecular Biology and Biochemistry, Almaty, Kazakhstan.
Gulzhakhan UtegenovaAitkhozhin Institute of Molecular Biology and Biochemistry, Almaty, Kazakhstan.
Ayaz BelkozhayevAitkhozhin Institute of Molecular Biology and Biochemistry, Almaty, Kazakhstan.
Altynay BalmukhanovaDepartment of Health Policy and Organization, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
Zaure DzhumatayevaKazakh Scientific Research Institute of Eye Diseases, Almaty, Kazakhstan.
Ainagul BeissovaDepartment of Public Health, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
Iryna ShargorodskaOphthalmology and Optometry department of Postgraduate Education, Bogomolets National Medical University, Kyiv, Ukraine.
Aigul BalmukhanovaInternational Medical School, Caspian University, Almaty, Kazakhstan.
Kamalidin SharipovAitkhozhin Institute of Molecular Biology and Biochemistry, Almaty, Kazakhstan.ORCID 0000-0001-5946-5521

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Diabetic retinopathy (DR) is the most common complication of diabetes, leading to blindness. The asymptomatic onset and the existing difficulties in diagnosing warrant the search for biomarkers that can facilitate the early diagnosis of DR. The aim of this study was to evaluate the potential of plasma microRNAs (miRNAs), which have previously been shown to be involved in the pathogenesis of DR and differentially expressed in plasma/serum of patients, as biomarkers for DR in the Kazakhstani population. Materials and Methods: Using quantitative RT-PCR, we compared the levels of ten candidate miRNAs in plasma among three groups: type 2 diabetes mellitus (T2DM) patients with DR (DR patients, Results: Level of miR-423-3p was significantly reduced in DR patients compared to noDR patients ( Conclusions: Due to the low specificity and small magnitude of deviations from the norm, the studied miRNAs have low potential in the diagnosis of DR.

Indexed as

Circulating MicroRNADiabetes Mellitus, Type 2Diabetic RetinopathyMicroRNAsAdultAgedBiomarkersCase-Control StudiesFemaleHumansKazakhstanMaleMiddle AgedROC CurveBiomarkersCirculating MicroRNAMicroRNAsBlood plasma biomarkerCirculating microRNADiabetic retinopathyType 2 diabetes mellitus

Identifiers

PMID40231069
PMCPMC11995893

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.