ArticleFrontiers in cardiovascular medicine2025
Clinical characteristics and mortality risk factors in pediatric hypertrophic, restrictive, and rapidly progressive hypertrophic cardiomyopathy: a retrospective cohort study with follow-up.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Pediatric cardiomyopathies are rare but life-threatening conditions with high mortality. Limited data exists on their clinical features and risk factors, especially in Asian populations, highlighting the need for further research in this area. Methods: This retrospective cohort study analyzed data from 212 pediatric patients diagnosed with hypertrophic cardiomyopathy (HCM), restrictive cardiomyopathy (RCM), or restrictive phenotype hypertrophic cardiomyopathy (RP-HCM) at a single center in China from October 2012 to October 2023, with follow-up until October 31, 2024. Demographic, clinical, and diagnostic data, as well as follow-up outcomes, were reviewed. Logistic and Cox regression models identified risk factors for in-hospital and long-term mortality. Results: Among the 212 patients, 79.72% (169/212) had HCM, 16.98% (36/212) had RCM, and 3.30% (7/212) had RP-HCM. Infection (75.47%, 160/212) and heart failure (51.42%, 109/212) were common comorbidities. In-hospital mortality was 5.19% (11/212), with follow-up mortality of 20.28% (43/212). The independent risk factors for mortality included left ventricular ejection fraction (LVEF), pulmonary hypertension, and low-density lipoprotein (LDL) levels ( Conclusions: This study underscores the importance of early diagnosis, genetic testing, and integrated management in pediatric cardiomyopathies. LVEF, pulmonary hypertension, and LDL levels are critical prognostic factors, offering insights for risk assessment and management in affected children.
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