Evidence map›Paper›PMID 40230844›Full record

ArticleFrontiers in immunology2025

Platelet secretions exert anti-inflammatory effects

Mohamed Samy Yousef, Ihshan Akthar, Dongxue Ma, Shingo Haneda, Kazuya Kusama, Masayuki Shimada, Kazuhiko Imakawa, Akio Miyamoto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohamed Samy YousefGlobal Agromedicine Research Center (GAMRC), Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
Ihshan AktharGlobal Agromedicine Research Center (GAMRC), Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
Dongxue MaGlobal Agromedicine Research Center (GAMRC), Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
Shingo HanedaDepartment of Clinical Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
Kazuya KusamaDepartment of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Masayuki ShimadaGraduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.
Kazuhiko ImakawaResearch Institute of Agriculture, Tokai University, Kumamoto, Japan.
Akio MiyamotoGlobal Agromedicine Research Center (GAMRC), Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Platelet derivatives improve the uterine immune environment and increase pregnancy success in humans and animals. Platelet-conditioned media (PCM) contain all molecules derived from platelets Methods: Platelets (10×10 Results: In PMNs, platelet secretions downregulated the mRNA expression of pro-inflammatory cytokines ( Conclusions: Our findings reveal for the first time that platelet secretions directly act on PMNs and BEECs

Indexed as

Anti-Inflammatory AgentsBlood PlateletsEndometriumEpithelial CellsNeutrophilsUterusAnimalsCattleCells, CulturedCulture Media, ConditionedCytokinesFemaleLipoxinsPregnancyAnti-Inflammatory AgentsCulture Media, ConditionedCytokinesLipoxinsanti-inflammatorycattleendometriumneutrophilsplatelets

Identifiers

PMID40230844
PMCPMC11994593

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.