ArticleCerebral circulation - cognition and behavior2025
The relation between cerebral small vessel function and white matter microstructure in monogenic and sporadic small vessel disease - the ZOOM@SVDs study.
Article in Cerebral circulation - cognition and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Brain endothelial GαEBioMedicine · 2026Article
- Imaging markers of vascular cognitive impairment: Current advances and future directions.Cerebral circulation - cognition and behavior · 2026Article
- Relation between Cerebral Small Vessel Function at 7T MRI and Small Vessel Disease Burden in a General Aging Population.Cerebrovascular diseases (Basel, Switzerland) · 2026Article
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Authors and funding
12 authors.
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Abstract
In cerebral small vessel disease (cSVD), vascular dysfunction has been associated with cSVD-lesions across the brain. Here we further explore the relation between vascular dysfunction and cSVD-related brain injury. We tested two hypotheses: (1) that complementary measures of abnormal small vessel function relate to decreased white matter integrity, and (2) that local variance in vascular dysfunction relates to local variance in white matter integrity within individual patients. We included 23 patients with monogenic cSVD (i.e. CADASIL) and 46 patients with sporadic cSVD. With whole-brain analyses, we tested if small vessel flow velocity and reactivity measures from 7T-MRI were associated with global peak-width-of-skeletonized-mean-diffusivity (PSMD). We also tested voxel-wise correlations between reactivity to hypercapnia and mean diffusivity (MD) in white matter. Whole-brain analyses showed a negative association between blood flow velocity and PSMD for the perforating arteries in the centrum semiovale in CADASIL (
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