ArticleFrontiers in veterinary science2025
Identification and profiling of microRNAs during sheep's testicular development.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- miRNA Sequencing and Differential Analysis of Testis in 1-Year-Old and 2-Year-Old Kazakh Horses.Biology · 2026Article
- Transcriptome Sequencing and Differential Analysis of Testes in One- and Two-Year-Old Kazakh Horses.Animals : an open access journal from MDPI · 2026Article
- Analysis of the characteristics of microRNA expression profiles and reproductive regulation-mediated signalling pathways in testicular sertoli derived sEVs from Leizhou goats.Veterinary research communications · 2026Article
- Review
- Article
- Identification of Critical States in Complex Biological Systems Using Cell-Specific Causal Network Entropy.Research (Washington, D.C.) · 2025Article
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Authors and funding
7 authors.
Funding
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Abstract
The normal development of the testis is essential for male reproduction, as it is the site of sperm production and a prerequisite for spermatogenesis. MiRNAs play crucial roles in various testicular biological processes, including cell proliferation, spermatogenesis, hormone secretion, metabolism, and reproductive regulation. In this study, we utilized deep sequencing data to analyze the expression patterns of small RNAs in testicular tissues of Southern × Hu sheep F1 hybrids at 0, 3, 6 months, and 1 year of age, thereby exploring the functions of miRNAs in testicular development and spermatogenesis. A total of 787 known miRNAs and 415 novel miRNAs were identified. We identified 217, 254, 405, 130, 305, and 138 DE miRNAs in the testes of M0 vs. M3, M0 vs. M6, M0 vs. Y1, M3 vs. M6, M3 vs. Y1, and M6 vs. Y1, respectively. GO annotation and KEGG pathway analysis of DE miRNA target genes revealed that target genes such as
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