ArticleCureus2025
Effect of Postconditioning With Intralipid in Patients Undergoing Off-Pump Coronary Artery Bypass Surgery: A Randomized Controlled Trial.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOff-pump coronary artery bypass (OPCAB) surgery is an alternative to conventional on-pump coronary artery bypass surgery for cardiac revascularization. It offers several advantages, including reduced mortality, decreased morbidity, and faster recovery. However, maintaining optimal myocardial function during OPCAB remains a challenge due to ischemia-reperfusion injury. Intralipid (IL), a fat emulsion used for parenteral nutrition, has shown potential cardioprotective effects. While the literature has elucidated IL's role as a preconditioning agent in OPCAB and a postconditioning agent in on-pump cardiac surgeries, its postconditioning role in OPCAB remains unexplored. This study aims to evaluate the postconditioning effects of IL in OPCAB surgery by measuring cardiac troponin I levels, hypothesizing that IL would reduce myocardial injury. METHODOLOGY: Forty patients scheduled for elective OPCAB were randomly assigned to the IL group (L group) (
resultsThe results revealed no significant difference in cTnI levels between the intralipid and control groups at any postoperative time point. Postoperative lipid profile, as well as renal and liver function, remained unaffected in all patients.
conclusionsAs evidenced by comparable postoperative cardiac enzyme levels between the intralipid and control groups, we did not find a postconditioning role of IL in OPCAB surgery, suggesting that IL may not provide cardioprotection in this setting. The authors propose a further investigation into alternative administration protocols (like varying doses and administration timings of IL) to elucidate its potential impact as a postconditioning agent in OPCAB.
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