Evidence map›Paper›PMID 40230651›Full record

ArticleMaterials today. Bio2025

Multifunctional micro/nano-textured titanium with bactericidal, osteogenic, angiogenic and anti-inflammatory properties: Insights from

Théo Ziegelmeyer, Karolinne Martins de Sousa, Tzu-Ying Liao, Rodolphe Lartizien, Alexandra Delay, Julien Vollaire, Véronique Josserand, Denver Linklater, Phuc H Le, Jean-Luc Coll and 3 more

Abstract read
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. A mechanically compliant SrTiOMaterials today. Bio · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Théo ZiegelmeyerUniversity Grenoble Alpes, INSERM U1209, CNRS UMR5309, Institute for Advanced Biosciences, F38000, Grenoble, France.
Karolinne Martins de SousaSchool of Science, RMIT University, Melbourne, VIC, 3000, Australia.
Tzu-Ying LiaoSchool of Science, RMIT University, Melbourne, VIC, 3000, Australia.
Rodolphe LartizienService de Chirurgie Maxillo-Faciale, Centre Hospitalier Annecy Genevois, 1 Avenue de L'hôpital, Epagny Metz-Tessy, F-74370, France.
Alexandra DelayUniversity Grenoble Alpes, INSERM U1209, CNRS UMR5309, Institute for Advanced Biosciences, F38000, Grenoble, France.
Julien VollaireUniversity Grenoble Alpes, INSERM U1209, CNRS UMR5309, Institute for Advanced Biosciences, F38000, Grenoble, France.
Véronique JosserandUniversity Grenoble Alpes, INSERM U1209, CNRS UMR5309, Institute for Advanced Biosciences, F38000, Grenoble, France.
Denver LinklaterDepartment of Biomedical Engineering, The Graeme Clark Institute, The University of Melbourne, Parkville, VIC, 3010, Australia.
Phuc H LeSchool of Science, RMIT University, Melbourne, VIC, 3000, Australia.
Jean-Luc CollUniversity Grenoble Alpes, INSERM U1209, CNRS UMR5309, Institute for Advanced Biosciences, F38000, Grenoble, France.
Georges BettegaUniversity Grenoble Alpes, INSERM U1209, CNRS UMR5309, Institute for Advanced Biosciences, F38000, Grenoble, France.
Elena P IvanovaSchool of Science, RMIT University, Melbourne, VIC, 3000, Australia.
Véronique Martel-FrachetUniversity Grenoble Alpes, INSERM U1209, CNRS UMR5309, Institute for Advanced Biosciences, F38000, Grenoble, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Titanium (Ti) is widely used as an implantable material for bone repair in orthopedics and dentistry. However, Ti implants are vulnerable to bacterial infections, which can compromise patient recovery and lead to implant failure. While a controlled inflammatory response promotes bone regeneration, chronic inflammation caused by infections can lead to implant failure. Bone repair is a complex process in which inflammation, angiogenesis and osteogenesis are tightly interconnected, requiring cooperation between mesenchymal stem cells (MSC), macrophages and endothelial cells. Here, we fabricated bio-inspired Ti implants with either microstructured (Micro Ti) or nanostructured (Nano Ti) surface textures that exhibit robust mechano-bactericidal properties.

Indexed as

Bioinspired mechano-bactericidal surfacesBone reconstructionOsseointegrationSurface topographyTitanium implants

Identifiers

PMID40230651
PMCPMC11994386

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.