Evidence map›Paper›PMID 40230571›Full record

ArticleEndoscopy international open2025

Efficacy and safety of multi-loop traction device-assisted colorectal endoscopic submucosal dissection: Multicenter randomized clinical trial.

Mamoru Ito, Yuko Miura, Yasuhiko Mizuguchi, Hiroto Furuhashi, Yosuke Tsuji, Hiroyuki Takamaru, Naoto Tamai, Mitsuhiro Fujishiro, Yutaka Saito, Kazuki Sumiyama

Abstract read
In one paragraph

Article in Endoscopy international open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mamoru ItoDepartment of Endoscopy, The Jikei University School of Medicine, Minato-ku, Japan.
Yuko MiuraDepartment of Gastroenterology, The University of Tokyo, Bunkyo-ku, Japan.
Yasuhiko MizuguchiEndoscopy Division, National Cancer Center Hospital, Chuo-ku, Japan.
Hiroto FuruhashiDepartment of Endoscopy, The Jikei University School of Medicine, Minato-ku, Japan.
Yosuke TsujiDepartment of Gastroenterology, The University of Tokyo, Bunkyo-ku, Japan.
Hiroyuki TakamaruEndoscopy Division, National Cancer Center Hospital, Chuo-ku, Japan.ORCID 0000-0002-7019-6331
Naoto TamaiDepartment of Endoscopy, The Jikei University School of Medicine, Minato-ku, Japan.
Mitsuhiro FujishiroDepartment of Gastroenterology, The University of Tokyo, Bunkyo-ku, Japan.ORCID 0000-0002-4074-1140
Yutaka SaitoEndoscopy Division, National Cancer Center Hospital, Chuo-ku, Japan.
Kazuki SumiyamaDepartment of Endoscopy, The Jikei University School of Medicine, Minato-ku, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and study aims: The multi-loop traction device (MLTD) facilitates optimal visualization of the submucosa throughout endoscopic submucosal dissection (ESD). This trial aimed to assess the efficacy of MLTD for colorectal ESD. Patients and methods: We conducted a multicenter, open-label, randomized controlled trial involving patients with colorectal lesions ≥ 20 mm suspicious for noninvasive carcinoma. Participants were randomly assigned in a 1:1 ratio to undergo ESD with MLTD (MLTD-ESD group) or ESD without any traction device (control group). Endoscopists were allowed to convert treatments if dissection became challenging for 10 minutes. The primary endpoint was dissection speed; secondary endpoints included technical success rate and adverse events (AEs). Results: A total of 108 participants were randomized to the MLTD-ESD group (n = 53) and the control group (n = 55). There was no statistically significant difference in median dissection speed between the MLTD-ESD group and the control group (14.8 mm Conclusions: This multicenter randomized trial demonstrated that use of MLTD did not significantly increase dissection speed for colorectal ESD. Treatment conversions may have influenced the primary endpoint, and further investigation is warranted.

Indexed as

Colorectal cancerEndoscopic resection (polypectomy, ESD, EMRc, ...)Endoscopy Lower GI TractPolyps / adenomas / ...

Identifiers

PMID40230571
PMCPMC11996020

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.