ArticleFrontiers in endocrinology2025
Usefulness of SPINA model in evaluation of the thyroid function in euthyroid pediatric patients children with subclinical hypothyroidism.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Reduced sensitivity to thyroid hormones is associated with differentiated thyroid cancer in the euthyroid thyroidectomy population.Frontiers in endocrinology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Subclinical hypothyroidism (SH) is biochemically defined by increased TSH and normal thyroid hormones, and its management is a matter of debate. Herein, we investigated thyroid function in euthyroid and children with SH using a structure parameter inference approach (SPINA) model along with published data from population-based TSH-FT4 curves. Design: The study included 183 children and adolescents with SH and 313 healthy controls. The predicted and actual secretory capacity of thyroid gland (SPINA-GT) was calculated in all euthyroid children divided into quartiles according to TSH values, and in children with SH, which were further subcategorized into those with mild SH (TSH: 4.5 - 10 mIU/L) and severe SH (TSH > 10 mIU/L). Results: Actual SPINA-GT values decreased significantly from the 1 Conclusion: The implementation of SPINA model for thyroid function gives a wider perspective of thyroid gland's performance within the euthyroid range of TSH, as well as in SH and add to the discussion for the nature of SH, and the necessity of its management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.