Evidence map›Paper›PMID 40230439›Full record

ArticleFrontiers in cellular and infection microbiology2025

Partial normalization of microbiota dysbiosis in condyloma acuminatum patients following treatment.

Kai Chen, Meng Li, Tian-Qi Fu, Yan-Yan Hu, Lan Chen, Qian Huang, Li Xu, Zhi-Liang Zeng, Dong-Sheng Li

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kai Chen *Department of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Meng Li *Department of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Tian-Qi Fu *Department of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yan-Yan HuDepartment of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lan ChenDepartment of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Qian HuangDepartment of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Li XuDepartment of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhi-Liang ZengDepartment of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Dong-Sheng LiDepartment of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Condyloma acuminatum (CA) is the most common sexually transmitted disease and the presence of microbiota dysbiosis has been observed to promote the progress of the disease. However, the explicit characteristics of microbiota dysbiosis in CA patients have not been well elucidated yet. Methods: We recruited 40 CA patients who received QYXJ (an in-hospital prescription that has been used to treat CA for many years) treatment and 40 healthy controls (HC) in the current study. Before and after two weeks QYXJ administration, the skin microbiome of each patient was assessed using 16S rRNA gene sequencing. Results: Here, we found increased relative abundances of Conclusion: This study further confirmed the changes of skin microbiome in CA pathogenesis and firstly revealed the protective effects of QYXJ in microbiota dysbiosis resolution, suggesting its potential role as a novel method for CA treatment.

Indexed as

Condylomata AcuminataDysbiosisMicrobiotaAdultBacteriaDNA, BacterialFemaleHumansMaleMiddle AgedRNA, Ribosomal, 16SSequence Analysis, DNASkinYoung AdultDNA, BacterialRNA, Ribosomal, 16Scondyloma acuminatum (CA)dysbiosis resolutionmicrobial interaction and functionmicrobiota dysbiosisskin microbiome

Identifiers

PMID40230439
PMCPMC11994705

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.