Evidence map›Paper›PMID 40230409›Full record

ArticleComputational and structural biotechnology journal2025

Mutagenesis-based optimal design of plant peptide phytosulfokine for enhanced biological activity.

Rui Ye, Chen Xu, Zhong-Jie Ding, Shao-Jian Zheng, Siewert-Jan Marrink, Dong Zhang, Ruhong Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rui YeInstitute of Quantitative Biology, School of Physics and College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Chen XuInstitute of Quantitative Biology, School of Physics and College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Zhong-Jie DingInstitute of Quantitative Biology, School of Physics and College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Shao-Jian ZhengInstitute of Quantitative Biology, School of Physics and College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Siewert-Jan MarrinkGroningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen 9747 AG, the Netherlands.
Dong ZhangInstitute of Quantitative Biology, School of Physics and College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Ruhong ZhouInstitute of Quantitative Biology, School of Physics and College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recognition of phytosulfokine (PSK), a sulfated pentapeptide, by its receptor PSKRs is crucial in regulating plant growth, development, and reproduction. However, designing highly active PSK remains a formidable challenge due to the lack of understanding of the structure-property relationship, structural dynamics, and the binding characteristics of PSK. Here, with a combined theoretical and experimental approach, we have investigated the binding dynamics of key interactions between PSK and AtPSKR1

Indexed as

Analogs designFree energy perturbationMolecular dynamicsMutagenesisPhytosulfokine

Identifiers

PMID40230409
PMCPMC11994915

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.