ArticleFrontiers in cellular neuroscience2025
A vascular endothelial cell, neuron, and microglia tri-culture model to study hypertension-related depression.
Article in Frontiers in cellular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- From Xenobiotic Exposure to Neuroinflammation: Mechanisms Linking Lipopolysaccharide Signaling to Depressive-like Behavior.Journal of xenobiotics · 2026Review
- Effect of Gouteng Jiangya Jieyu Prescription on Neuronal Damage in Rats With Hypertension Complicated by Depression via ROS/AKT/NF-κB Pathway.Pulmonary circulation · 2026Article
- Article
- DIA-based proteomics reveals anti-inflammatory role of DL-3-Translational neuroscience · 2025Article
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10 authors.
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Abstract
Hypertension-related Depression (HD) is a complex mental disorder that exerts a significant negative impact on patients' quality of life. Previous studies have demonstrated that damages to vascular endothelial and hippocampus are the primary pathological features in HD rats. Under hypertensive conditions, inflammatory cytokines in peripheral blood vessels can induce central nervous system inflammation through penetration of a damaged blood-brain barrier, peripheral immune cells, and neural pathways, damaging the brain and triggering HD. Therefore, interactions between vascular endothelial cells, neurons, and glial cells are critical for the understanding of HD. However,
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