Evidence map›Paper›PMID 40230289›Full record

ArticleActa biochimica et biophysica Sinica2025

Transcription factor occupancy limits DNA methylation and determines ICAM1 expression in breast cancer.

Mingcang Chen, Ying Zhou, Zhengwei Fu, Chunyu Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mingcang ChenCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.
Ying ZhouDepartment of Peripheral Vascular, Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200082, China.
Zhengwei FuCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.
Chunyu WuDepartment of Breast Surgery (Integrated Traditional and Western Medicine), Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The interaction between TF binding and DNA methylation is increasingly recognized as a key player in the regulation of gene expression. However, the role of this interaction in regulating ICAM1 expression in breast cancer has not been elucidated. CpG methylation in the

Indexed as

Breast NeoplasmsDNA MethylationGene Expression Regulation, NeoplasticIntercellular Adhesion Molecule-1Transcription FactorsCell Line, TumorCpG IslandsFemaleHumansPromoter Regions, GeneticTranscription Factor RelAICAM1 protein, humanIntercellular Adhesion Molecule-1RELA protein, humanTranscription Factor RelATranscription Factorsbreast cancercompetitionDNA methylationintercellular adhesion molecule 1transcription factor binding

Identifiers

PMID40230289
PMCPMC12130730

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.