ArticleDiabetes, obesity & metabolism2025
Chronic kidney disease risk assessment: Findings from backward-looking study using annual health check-up data in Japan.
Article in Diabetes, obesity & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Dietary inflammatory index and mortality in middle-aged and elderly patients with metabolic syndrome.Diabetology & metabolic syndrome · 2025Article
- Chronic kidney disease risk assessment: Findings from backward-looking study using annual health check-up data in Japan.Diabetes, obesity & metabolism · 2025Article
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Authors and funding
5 authors.
Funding
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Abstract
AIMS/
introductionWhile studies on kidney disease (KD) in patients with severe metabolic syndrome (MetS) have been reported, research on undiagnosed MetS individuals is limited. This study aimed to investigate KD mechanisms in early MetS stages among Japanese individuals to establish accurate KD prediction models applicable to specific health guidance using annual health check-up (HC) data. MATERIALS AND
methodsCox regression analysis was conducted using the Kokuho Database including HC and claims data over the past 10 years. Survival time was defined as the period from the initial HC during the observation period until estimated glomerular filtration rate (eGFR) fell below the following cut-offs: 60 mL/min/1.73 m
resultsSignificant increases in hazard ratios (HRs) for BMI, HbA1c, TG and SBP were observed for primary and additional cut-offs. BMI, HbA1c and TG showed progressively stronger HR increases with advancing stages. The model for all scenarios demonstrated goodness of fit with the high C-statistics.
conclusionsThis study highlights the necessity of a comprehensive evaluation of MetS factors in CKD risk assessment and shows the model using annual HC data can identify CKD progression effectively and accurately. A risk assessment approach considering multiple CKD stages will be crucial for early intervention and disease prevention strategies.
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