Evidence map›Paper›PMID 40230051›Full record

ArticleJournal of hepato-biliary-pancreatic sciences2025

Carbon-ion irradiation together with autophagy inhibition and immune checkpoint inhibitors protect against pancreatic cancer development in mouse model.

Makoto Sudo, Yaoyao Wang, Jingren Wang, Koubun Yasuda, Keiko Mitani, Shuhei Hayashi, Masaki Ohmuraya, Hiroko Tsutsui, Jiro Fujimoto

Abstract read
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In one paragraph

Article in Journal of hepato-biliary-pancreatic sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Makoto SudoDepartment of Genetics, School of Medicine, Hyogo Medical University, Hyogo, Japan.ORCID https://orcid.org/0009-0000-5042-5371
Yaoyao WangDepartment of Genetics, School of Medicine, Hyogo Medical University, Hyogo, Japan.
Jingren WangDepartment of Genetics, School of Medicine, Hyogo Medical University, Hyogo, Japan.
Koubun YasudaDepartment of Immunology, School of Medicine, Hyogo Medical University, Hyogo, Japan.ORCID https://orcid.org/0000-0002-3533-1702
Keiko MitaniDepartment of Gastroenterological Surgery, School of Medicine, Hyogo Medical University, Hyogo, Japan.
Shuhei HayashiDepartment of Microbiology, School of Medicine, Hyogo Medical University, Hyogo, Japan.ORCID https://orcid.org/0000-0001-7004-7339
Masaki OhmurayaDepartment of Genetics, School of Medicine, Hyogo Medical University, Hyogo, Japan.ORCID https://orcid.org/0000-0001-9707-3932
Hiroko TsutsuiDepartment of Gastroenterological Surgery, School of Medicine, Hyogo Medical University, Hyogo, Japan.ORCID https://orcid.org/0000-0001-7928-4875
Jiro FujimotoDepartment of Gastroenterological Surgery, School of Medicine, Hyogo Medical University, Hyogo, Japan.ORCID https://orcid.org/0000-0002-2757-9011

Funding

Japan Society for the Promotion of Science JP21H03011
6 · The paper itself

Abstract

backgroundPancreatic cancer remains fatal because of resistance to chemo-, radio-, and immunotherapies. Carbon-ion radiotherapy (CIRT) has been beneficial for patients with pancreatic cancer. The purpose of this study was to identify the mechanism by which CIRT exerts its anticancer activity, particularly in combination with immunotherapy.

methodsWe implanted murine pancreatic cancer cells treated with CIRT and autophagy inhibitor HCQ (CIRT+HCQ) into syngeneic mice, followed by the application of a regulatory T (Treg) cell blockade using immune-checkpoint inhibitors. We compared CIRT+HCQ-treated tumors with those implanted without any treatment. Further, we also implanted CIRT+HCQ-treated pancreatic tumors into CD8

resultsCIRT+HCQ-treated tumors exhibited reduced growth, higher numbers of CD8

conclusionsTreg cell-targeted therapy exerted an anticancer effect in mice bearing CIRT+HCQ-treated tumors but not in those bearing untreated pancreatic tumors by activating cancer-specific CD8

Indexed as

AutophagyHeavy Ion RadiotherapyImmune Checkpoint InhibitorsPancreatic NeoplasmsAnimalsCD8-Positive T-LymphocytesCell Line, TumorDisease Models, AnimalMiceMice, Inbred C57BLT-Lymphocytes, RegulatoryImmune Checkpoint InhibitorsautophagyCD8+ T‐lymphocytesheavy ion radiotherapypancreatic cancerregulatory T cells

Identifiers

PMID40230051
PMCPMC12276459

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.