Evidence map›Paper›PMID 40229921›Full record

Observational studyAnnals of African medicine2025

Diagnostic Accuracy of Adenosine Deaminase Levels in Peripheral Blood Lymphocyte of Patients with Pulmonary Tuberculosis.

Ashish Anantrao Jadhav, Ashok Kumar, Alkesh Kumar Khurana, Jagat Rakesh Kanwar, Ashwin Kotnis, Suryabhan Lahanu Lokhande

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Annals of African medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Ashish Anantrao JadhavDepartment of Biochemistry, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
Ashok KumarDepartment of Biochemistry, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
Alkesh Kumar KhuranaDepartment of Pulmonary Medicine and Tuberculosis, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
Jagat Rakesh KanwarDepartment of Biochemistry, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
Ashwin KotnisDepartment of Biochemistry, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
Suryabhan Lahanu LokhandeDepartment of Biochemistry, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextTuberculosis (TB) is a well-known global health problem with one-fifth of the global burden in India. Although there are diagnostic and prognostic markers for TB, there is lack of specificity and sensitivity of diagnostic methods.

aimsThe goal of this study was to assess the diagnostic value of blood lymphocyte adenosine deaminase (ADA) levels in pulmonary TB patients. SUBJECTS AND

methodsThis was a prospective observational case-control study. A total of 80 subjects were included in this study and were divided into two groups: 40 people who were healthy in every respect and 40 patients with pulmonary TB. ADA activity was measured in each group by the Giusti and Galanti method using a commercial kit. STATISTICAL ANALYSIS USED: Data were analyzed using t -test with receiver operating characteristic curve analysis done to identify the cutoff values for ADA that had maximum sensitivity and specificity.

resultsThe mean serum ADA level in the pulmonary TB group was significantly increased as compared to control group ( P < 0.0001), whereas blood lymphocyte ADA levels as well as blood lymphocyte/serum ADA ratio in the pulmonary TB group were significantly decreased as compared control group ( P < 0.0001). In regard to the cutoff value of <34.06 IU/mg protein in patients with pulmonary TB, sensitivity and specificity were 90.00% and 80.00%, respectively.

conclusionsBlood lymphocyte ADA level may be used as a biomarker for the diagnosis of pulmonary TB.

Indexed as

Adenosine DeaminaseLymphocytesTuberculosis, PulmonaryAdultBiomarkersCase-Control StudiesFemaleHumansIndiaMaleMiddle AgedProspective StudiesROC CurveSensitivity and SpecificityYoung AdultAdenosine DeaminaseBiomarkersAdenosine deaminaseAdénosine désaminaseblood lymphocytediagnosisdiagnosticet spécificitélymphocytes sanguinssensibilitésensitivity and specificitytuberculosetuberculosis

Identifiers

PMID40229921
PMCPMC12588405

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