ArticleEuropean journal of medical research2025
Characteristics of cortical thickness in treated HIV-infected individuals with and without cognitive impairment.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Microglial reactivity and nodule formation are associated with Synaptodendritic damage in the brains of people with HIV-1.Brain pathology (Zurich, Switzerland) · 2026Article
- A rest-task fMRI study of spatial working memory in HIV-infected individuals across cognitive states.BMC medical imaging · 2026Article
- Epigenetic mechanisms of HIV and opioid-induced neuropathology: Potential therapies and interventions.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
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6 authors.
Funding
Abstract
backgroundHIV can alter the brain structure and function in the early stage of infection. This study investigated the differences in cortical thickness patterns between healthy controls (HCs) and people living with HIV (PLWH) with asymptomatic neurocognitive impairment (ANI) or cognitive integrity (CI).
methodsTwenty-one ANI, 25 CI, and 24 HCs were recruited and underwent high-resolution T1-weighted magnetic resonance images. Cortical thickness was analyzed using the Computational Anatomy Toolbox, and the correlation analysis was conducted between cortical thickness and clinical and neuropsychological variables.
resultsBoth CI and ANI exhibited decreased cortical thickness, primarily in the left frontal cortices and bilateral limbic system. ANI demonstrated a more pronounced and widespread pattern of cortical thinning. Lower CD4
conclusionsThe cortical thickness thinning was observed in the frontal and limbic systems in both ANI and CI. Meanwhile, the thickening of the insular cortex may represent mild neuroinflammation or a transient compensatory mechanism. This study provides new insights into the neural mechanisms underlying HIV-related cognitive impairment and highlights the importance of cortical thickness alteration patterns when assessing cognitive function of PLWH.
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