Evidence map›Paper›PMID 40229898›Full record

ArticleBMC rheumatology2025

IgA vasculitis associated with chronic myelomonocytic leukemia.

Bénédicte Rouvière, Francois Chasset, Noémie Abisror, Pierre Hirsch, Olivier Fain, Arsène Mékinian, MINHEMON (French network on immune diseases associated with hemopathies and cancers)

Abstract read
In one paragraph

Article in BMC rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Heterogeneity of monocytes in cancer.American journal of cancer research · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bénédicte RouvièreDepartment of Internal Medicine and Pneumology, Brest University Hospital, Brest, France. benedicte.rouviere@chu-brest.fr.
Francois ChassetFaculty of Medicine, AP-HP, Dermatology and Allergology Department, Tenon Hospital, Sorbonne University, Paris, 75020, France.
Noémie AbisrorDepartment of Internal Medicine, Saint-Antoine Hospital, APHP, Sorbonne University, Paris, France.
Pierre HirschFaculty of Medicine, Biological Hematology Department, Hôpital Saint Antoine, AP-HP, Sorbonne University, Paris, 75012, France.
Olivier FainDepartment of Internal Medicine, Saint-Antoine Hospital, APHP, Sorbonne University, Paris, France.
Arsène MékinianDepartment of Internal Medicine, Saint-Antoine Hospital, APHP, Sorbonne University, Paris, France. arsene.mekinian@aphp.fr.
MINHEMON (French network on immune diseases associated with hemopathies and cancers)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IgA vasculitis is a predominantly pediatric autoimmune disease characterized by IgA deposit in small vessels. Chronic myelomonocytic leukemia (CMML) is a rare hematological malignancy classified within myelodysplastic syndromes. Here, we present a previously unrecognized case of CMML associated with IgA vasculitis. A 62-year-old woman presented with necrotic and infiltrated purpura and mild arthralgia, primarily affecting the knees and wrists, without gastrointestinal or kidney involvement. A comprehensive screening for other etiologies was unremarkable. Blood tests showed an increase of monocyte count and circulating monocyte phenotyping was consistent with CMML. Bone marrow analysis showed no blast cells or karyotypic abnormalities. Genetic testing identified an NRAS mutation. Autoantibody screening and viral serologies were negative. A skin biopsy revealed small-vessel vasculitis with IgA immune deposits. CMML can be associated with autoimmune diseases, such as polyarteritis nodosa and cutaneous leukocytoclastic vasculitis. However, this is the first report of IgA vasculitis occurring in the context of low risk CMML.

Indexed as

Autoimmune disordersChronic myelomonocytic leukemiaIgA vasculitisPurpura

Identifiers

PMID40229898
PMCPMC11995566

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.