Evidence map›Paper›PMID 40229836›Full record

ArticleBMC ophthalmology2025

CDK4/6 inhibitor-associated vortex keratopathy: a case report.

Lian Shu, Xinhan Cui, Yan Wang, Xinghuai Sun

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lian ShuDepartment of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, No.83 Fenyang Road, Shanghai, 200031, China.
Xinhan CuiDepartment of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, No.83 Fenyang Road, Shanghai, 200031, China.
Yan WangDepartment of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, No.83 Fenyang Road, Shanghai, 200031, China.
Xinghuai SunDepartment of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, No.83 Fenyang Road, Shanghai, 200031, China. xhsun@shmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCyclin-dependent kinase (CDK) 4/6 inhibitors are novel anticancer drugs that can arrest the cell cycle and halt the progression of cancers. This study presents a rare case of vortex keratopathy associated with the use of a cyclin-dependent kinase (CDK) 4/6 inhibitor for breast cancer treatment. PATIENT PRESENTATION: A 60-year-old female patient with a one-year history of eye irritation presented at our hospital. She had been diagnosed with metastatic breast cancer two years prior and received treatment with tiremciclib (a novel CDK4/6 inhibitor) in combination with fulvestrant at the same time. After slit-lamp examination, anterior segment optical coherence tomography (AS-OCT), and corneal confocal microscopy, the patient was diagnosed with vortex keratopathy. The ocular symptoms of the patient improved slightly after the use of artificial lubricating eye drops.

conclusionsThis case demonstrates the ocular characteristics and novel findings of corneal confocal microscopy of CDK4/6 inhibitor-related vortex keratopathy. Our findings increase the understanding of the pathophysiological mechanisms of drug-induced vortex keratopathy and increase our awareness of ocular manifestations in patients receiving novel anticancer drugs.

Indexed as

Antineoplastic AgentsCorneal DiseasesCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Protein Kinase InhibitorsBreast NeoplasmsFemaleFulvestrantHumansMicroscopy, ConfocalMiddle AgedTomography, Optical CoherenceAntineoplastic AgentsCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6FulvestrantProtein Kinase InhibitorsCDK4/6 inhibitorCorneal confocal microscopyCorneal verticillateVortex keratopathy

Identifiers

PMID40229836
PMCPMC11995518

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.