Evidence map›Paper›PMID 40229755›Full record

SynthesisBMC public health2025

Exploring the health complications of female genital mutilation through a systematic review and meta-analysis.

Christina Pallitto, Fernando Ruiz-Vallejo, Vernon Mochache, Karin Stein, Joshua P Vogel, Max Petzold

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Sexual health interventions for treating sexual dysfunction in women with female genital mutilation: A systematic review.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Pooled it
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  6. Observational
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  9. "Frontiers in global women's health · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christina PallittoDepartment of Sexual and Reproductive Health and Research, and the UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), World Health Organization, 20 Avenue Appia, Geneva, 1211, Switzerland. pallittoc@who.int.
Fernando Ruiz-VallejoFacultad de Medicina, Universidad Nacional de Colombia, Bogota, Colombia.
Vernon MochacheDepartment of Sexual and Reproductive Health and Research, and the UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), World Health Organization, 20 Avenue Appia, Geneva, 1211, Switzerland.
Karin SteinDivision of Healthier Populations, World Health Organization, Geneva, Switzerland.
Joshua P VogelBurnet Institute, Melbourne, VIC, Australia.
Max PetzoldSchool of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.

Funding

World Health Organization 001
6 · The paper itself

Abstract

backgroundFemale genital mutilation (FGM) is a harmful practice that affects an estimated 230 million women and girls. Previous research indicates that FGM is associated with increased risk of short- and long-term health complications. Understanding the health complications is important in ensuring high quality care for women and girls already affected and for advocating for prevention of the practice.

objectiveThe objective of this study was to conduct a systematic review and meta-analysis of all existing evidence on the association between FGM and a range of health complications.

methodsWe conducted a systematic review of the literature on the health complications of FGM published between February 2009 and December 2022, applying search strategies and terms aligned with previous reviews. We identified studies that compared women with various types of FGM versus those without for six domains of health complications (i.e., immediate, obstetric & neonatal, gynecological, urological, sexual and mental). Random effects meta-analysis was conducted by health condition and FGM type. Immediate health complications were analysed separately based on data from population-based surveys.

resultsWe analysed data from 78 studies (n = 486,949), of which 67 informed the meta-analyses comparing women with and without FGM and 11 informed analyses on the immediate health complications. Most of the studies (N = 68) were conducted in high FGM prevalence countries. Among women and girls living with FGM compared to those without, we found an increased risk for obstetric complications, including prolonged/obstructed labor, obstetric tears, caesarean birth, postpartum hemorrhage, episiotomy, fetal distress, extended maternal hospital stay, neonatal asphyxia, and stillbirth/neonatal death; gynecological complications, including genital tissue damage, genitourinary tract infections, and menstrual difficulties; urological complications, including urinary tract infections and difficulty urinating; sexual complications including dyspareunia and sexual dysfunction; and mental health complications including depression or anxiety and somatoform disorder.

conclusionThese results support results from previous research finding an association between FGM and a range of health complications over the life course. This calls for strengthening health systems to provide high-quality care for women and girls at-risk of or affected by FGM and ensuring that FGM prevention and care services are included in essential health service packages.

Indexed as

Circumcision, FemaleFemaleHumansPregnancyFemale genital mutilationFGCFGMHealth burdenMental healthReproductive healthSexual health

Identifiers

PMID40229755
PMCPMC11995580

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.