Trial reportBMC cancer2025
The impact of a single HIIT intervention on the mobilization of NK cells and ILCs in adolescents and young adults (AYA) undergoing cancer treatment: an interventional controlled trial.
Trial report in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05656651 (ACTIVE- Acute Effects of a Single Physical Exercise Intervention on Immune Cells and Inflammation in Cancer Patients and a Healthy Comparison Group), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ACTIVE- Acute Effects of a Single Physical Exercise Intervention on Immune Cells and Inflammation in Cancer Patients and a Healthy Comparison Group
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Physical activity, sedentary behavior and ovarian cancer risk in Asian populations: a scoping review and meta-analysis.BMC cancer · 2026Pooled it
- High-Intensity Interval Training Boosts Immune Cells in Advanced Cancer Patients and Healthy Controls: Implications for Cancer Care.Cancer medicine · 2026Trial
- Comparison and analysis of the immune landscape at the tumour invasion front in patients with pMMR/MSI-H and pMMR/MSS colorectal cancer.International journal of colorectal disease · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe study investigated the response of immune cells, particularly natural killer (NK) cells and innate lymphoid cells (ILCs), to acute exercise in adolescents and young adults (AYAs) undergoing cancer treatment, to lower their treatment burden and evaluate the value of exercise in this vulnerable cohort.
methodsAn AYA cancer patient group (PG) (n = 20, 25 ± 7 years old) and an age-matched healthy control group (HG) (n = 20, 27 ± 5 years old) completed a twenty-minute high intensity interval training (HIIT) on a bicycle ergometer. Blood was taken at three timepoints during the intervention. Once immediately before (T0), once immediately after the intervention (T1), and after one-hour of recovery (T2). NK cells, ILCs, respectively their subpopulations, were determined by flow cytometry.
resultsTotal NK cells (PG: p = 0.023; HG: p = 0.004), CD56
conclusionWe were able to show, that HIIT enhances the mobilization of NK cells and ILCs to the same extend in AYA cancer patients than in healthy controls. Our pilot study revealed, that exercise is likely to play an important role in the defense against pathogens and neoplastic cells and that AYA cancer patients might benefits from regular exercise programs during anti-cancer treatment.
trial registrationThe study was registered on 13.11.2022, registration number NCT05656651, in the international register of clinical trials https://www. CLINICALTRIALS: gov/ .
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