Evidence map›Paper›PMID 40229687›Full record

ArticleBMC infectious diseases2025

Infection control rate in two-stage exchange for chronic periprosthetic joint infection: a retrospective cohort study focusing on antibiotic-free period.

Haiqi Ding, Xuhui Yuan, Yang Chen, Changyu Huang, Hongxin Hu, Yufeng Guo, Chengguo Huang, Xinyu Fang, Wenming Zhang

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Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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9 authors.

Haiqi Ding *Department of Orthopaedic Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Xuhui Yuan *Department of Orthopaedic Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Yang ChenDepartment of Orthopaedic Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Changyu HuangDepartment of Orthopaedic Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Hongxin HuDepartment of Orthopaedic Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Yufeng GuoDepartment of Orthopaedic Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Chengguo HuangDepartment of Orthopaedic Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Xinyu FangDepartment of Orthopaedic Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. fangxinyu0417@fjmu.edu.cn.
Wenming ZhangDepartment of Orthopaedic Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. zhangwm0591@fjmu.edu.cn.

Funding

Fujian Provincial Health Technology Project 2023ZQNZD007Fujian Re-search and Training Grants for Young and Middle-aged Leaders in Healthcare 2023ZQNRCYX-FXYJoint Funds for the Innovation of Science and Technology, Fujian Province, China 2022Y4003
6 · The paper itself

Abstract

backgroundLimited information is available regarding the impact of antibiotic holidays on the infection control rate of two-stage revisions for chronic periprosthetic joint infection (PJI). This study aims to evaluate the impact of an antibiotic holiday on the infection control rate after two-stage exchange for PJI.

methodsWe retrospectively analyzed data from patients with chronic PJI who underwent long-interval two-stage exchange using joint spacers at our center from June 2012 to June 2021. Patients were divided into Short Antibiotic Holiday (SAH, antibiotic holiday < 3 months) and Long Antibiotic Holiday (LAH, antibiotic holiday ≥ 3 months) groups. Following completion of the two-stage exchange treatment, patients were monitored for a minimum of 2 years to determine the infection control rate.

resultsA total of 75 chronic PJI patients were included, comprising 42 hip and 33 knee cases. In chronic PJI of the hip, the LAH group demonstrated a significantly higher infection control rate compared to the SAH group (27/27 vs 12/15, p = 0.016). For chronic PJI of the knee, the infection control rate in the LAH group was comparable to that in the SAH group (20/21 vs 10/12, p = 0.238). Furthermore, no significant differences in clinical outcomes were observed between the LAH and SAH groups.

conclusionsA ≥ 3-month antibiotic holiday, without compromising postoperative functional recovery, may enhance infection control rates after two-stage exchange for chronic hip PJI using joint spacers.

Indexed as

Anti-Bacterial AgentsInfection ControlProsthesis-Related InfectionsAgedAged, 80 and overChronic DiseaseFemaleHumansMaleMiddle AgedReoperationRetrospective StudiesAnti-Bacterial AgentsAntibiotic holidayArticulating spacerInfection control ratePeriprosthetic joint infectionTwo-stage exchange

Identifiers

PMID40229687
PMCPMC11995641

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.