Evidence map›Paper›PMID 40229673›Full record

ArticleBMC genomics2025

Epidemiological characteristics and genomic analysis of respiratory adenovirus in Jining City from February 2023 to July 2024.

Huixin Dou, Chunmei Chen, Tongyun Song, Xu Sun, Feifei He, Yongjian Jia, Xiaoyu Wang, Yajuan Jiang, Ying Yue, Shiqing Huang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Huixin Dou *School of Bioengineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China.
Chunmei Chen *Department of Laboratory, Rencheng Center for Disease Control and Prevention, Jining, 272000, China.
Tongyun SongDepartment of Laboratory, Rencheng Maternal and Child Health Hospital, Jining, China.
Xu SunDepartment of Laboratory, Jining Center for Disease Control and Prevention, Jining, 272000, China.
Feifei HeComputer Information Technology, Northern Arizona University, Flagstaff, AZ, 86011, USA.
Yongjian JiaDepartment of Laboratory, Jining Center for Disease Control and Prevention, Jining, 272000, China.
Xiaoyu WangDepartment of Laboratory, Jining Center for Disease Control and Prevention, Jining, 272000, China.
Yajuan JiangDepartment of Laboratory, Jining Center for Disease Control and Prevention, Jining, 272000, China.
Ying YueComputer Information Technology, Northern Arizona University, Flagstaff, AZ, 86011, USA.
Shiqing HuangComputer Information Technology, Northern Arizona University, Flagstaff, AZ, 86011, USA.
ShiGan YanSchool of Bioengineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China. yanshigan@126.com.
Boyan JiaoDepartment of Laboratory, Jining Center for Disease Control and Prevention, Jining, 272000, China. j198319831983@126.com.
Baihai JiaoDepartment of Infectious Disease Control, Jining Center for Disease Control and Prevention, Jining, China. Bjiao@uchc.edu.

Funding

Science and Technology Development Funds for Shandong Medical and Health 202112060725
6 · The paper itself

Abstract

backgroundHuman adenovirus (HAdV) infection can cause high fever, pneumonia, and even death, posing a serious threat to human health. This study analyzes the epidemiological characteristics and genetic features of respiratory adenovirus in Jining City from February 2023 to July 2024.

methodsFrom February 2023 to July 2024, 3,947 throat swab specimens were collected from influenza-like illness cases at Jining First People's Hospital and Rencheng District Maternal and Child Health Hospital. Real-time fluorescent quantitative PCR was used to detect HAdV nucleic acid. Whole-genome sequencing was performed on HAdV-positive samples. Phylogenetic trees were constructed for the whole genome, Penton base gene, Hexon gene, and Fiber gene of HAdV, and protein variation sites were analyzed.

resultsThe HAdV positivity rate in influenza-like cases in Jining City from February 2023 to July 2024 was 3.42% (135/3947), with higher positivity rates in younger age groups. HAdV positivity rates were higher between December 2023 and July 2024, while lower between January 2023 and November 2023. Whole-genome sequencing was performed on 47 HAdV samples, revealing 38 cases of HAdV-B and 9 cases of HAdV-C, with no HAdV-E detected. HAdV-B and HAdV-C co-circulated in Jining City from February to December 2023, while HAdV-B predominated from January to July 2024. All 38 HAdV-B sequences from Jining City are HAdV-3. In the phylogenetic trees of the whole genome, Penton base gene, Hexon gene, and Fiber gene of HAdV-B, all 38 HAdV-B strains from Jining City are located in the same evolutionary branch as the Chinese HAdV-3 candidate vaccine strain Guangzhou01. Compared to Guangzhou01, the RGD motif in Penton base and antigenic epitopes in Hexon of the 38 HAdV-B strains from Jining remained unchanged. Among the 9 HAdV-C sequences from Jining, 4 were identified as HAdV-104 and 5 as HAdV-108. The RGD motif in Penton base protein and receptor-binding sites in Fiber protein remained unchanged in all 9 HAdV-C sequences.

conclusionsFrom February 2023 to July 2024, HAdV in Jining City primarily circulated among younger age groups in influenza-like illness cases, with no apparent seasonal pattern. Enhanced surveillance of HAdV and accelerated development and marketing of HAdV vaccines are necessary.

Indexed as

Adenoviruses, HumanAdenovirus Infections, HumanGenome, ViralAdolescentAdultAgedChildChild, PreschoolChinaFemaleGenomicsHumansInfantMaleMiddle AgedPhylogenyAntigenic epitopesHuman adenovirusInfluenza-like illnessWhole-genome sequencing

Identifiers

PMID40229673
PMCPMC11995490

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.