Evidence map›Paper›PMID 40229617›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2026

Causal atlas on comorbidities in cardiomyopathy: a Mendelian randomization study of European ancestry.

Mengting Sun, Ming Gao, Peng Huang, Manjun Luo, Tingting Wang, Xiaorui Ruan, Kebin Chen, Jiapeng Tang, Ye Chen, Jiabi Qin

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Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Mengting SunDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.
Ming GaoDepartment of Geriatric Medicine, Center of Coronary Circulation, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Peng HuangDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
Manjun LuoDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.
Tingting WangDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.
Xiaorui RuanDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.
Kebin ChenDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.
Jiapeng TangDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.
Ye ChenDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.
Jiabi QinDepartment of Maternal, Child and Adolescent Health, School of Public Health, Kunming Medical University, 1168 Chunrong West Road, Yuhua Street, Chenggong District, Kunming, 650500, Yunnan Province, China. qinjiabi123@163.com.ORCID http://orcid.org/0000-0002-9360-4991

Funding

Changsha Municipal Natural Science Foundation kq2202470China Postdoctoral Science Foundation 2020M682644Graduate School-Enterprise Joint Innovation Project of Central South University 2024XQLH048Hunan Outstanding Youth Fund Project 2022JJ10087Hunan Provincial Key Research and Development Program 2018SK2063Hunan Provincial Science and Technology Talent Support Project 2020TJ-N07National Key Research and Development Project 2018YFE0114500Natural Science Foundation of Hunan Province 2018JJ2551Natural Science Foundation of Hunan Province 2022JJ40207Open Project from NHC Key Laboratory of Birth Defect for Research and Prevention KF2020006Science and Technology Planning Project of Guangdong Province 2020A1414010152the National Natural Science Foundation Program of China 81803313the National Natural Science Foundation Program of China 82073653
6 · The paper itself

Abstract

backgroundCardiomyopathy (CM) is often accompanied by comorbidities that increase the risk of death. Our aim is to explore the causal association between CM and its subtypes and various related comorbidities.

methodsBidirectional Mendelian randomization (MR) was used to explore the causal association between 39 comorbidities and CM, 13 comorbidities and hypertrophic cardiomyopathy (HCM), 25 comorbidities and dilated cardiomyopathy (DCM), and 13 comorbidities and restrictive cardiomyopathy (RCM). Besides, we explored the causal associations between systolic, diastolic, and pulse pressure with CM and DCM, respectively. MR Mediation analysis was used to explore whether atrial fibrillation (AF) or hypertension was as mediating variable mediating the causal association between each other and CM.

resultsBy MR analysis, we found that AF (OR = 1.28) and hypertension (OR = 3.58) were associated with an increased risk of CM, and CM was causally associated with an increased risk of heart failure (OR = 1.40). In addition, hypertension was causally associated with a lower risk of DCM (OR = 0.22). The results of the causal association of systolic, diastolic, and pulse pressure with CM and DCM were consistent with the direction of the causal association of hypertension with CM and DCM. Through MR Mediation analysis, we found AF as a mediating factor mediates the causal association between hypertension and CM, with a mediating proportion of about 16.22%.

conclusionsThis study is the first to reveal the causal association between certain comorbidities and CM and DCM, and to find possible mediating effects among them.

Indexed as

CardiomyopathiesHypertensionMendelian Randomization AnalysisWhite PeopleAtrial FibrillationComorbidityHumansMaleRisk FactorsWhiteCardiomyopathyCausal associationComorbiditiesMediating effectMendelian randomization

Identifiers

PMID40229617

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.