Evidence map›Paper›PMID 40229604›Full record

ArticleJournal of general internal medicine2025

Racial Disparities in Septic Shock Outcomes: A Nationwide Analysis (2016-2020).

Adeel Nasrullah, Mohammed A Quazi, Muhammad Hassan Shakir, Eiraj Khan, Amir H Sohail, Muhammad Ibraiz Bilal, Taimur Muzammil, Abu Baker Sheikh, Muhammad Adrish, Tariq Cheema

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Article in Journal of general internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

10 authors.

Adeel NasrullahDivision of Pulmonary and Critical Care, Allegheny Health Network, Pittsburgh, PA, USA.
Mohammed A QuaziDepartment of Psychiatry and Behavioral Sciences, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Muhammad Hassan ShakirDepartment of Internal Medicine, The Wright Center for Graduate Medical Education, Scranton, PA, USA.
Eiraj KhanDepartment of Internal Medicine, Allegheny Health Network, 7 Allegheny Center, Pittsburgh, PA, USA.
Amir H SohailDepartment of Surgery, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Muhammad Ibraiz BilalDepartment of Internal Medicine, Allegheny Health Network, 7 Allegheny Center, Pittsburgh, PA, USA. ibraiz47@hotmail.com.ORCID 0000-0002-8413-6006
Taimur MuzammilDepartment of Internal Medicine, Allegheny Health Network, 7 Allegheny Center, Pittsburgh, PA, USA.
Abu Baker SheikhDepartment of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Muhammad AdrishDivision of Pulmonary and Critical Care, Baylor College of Medicine, Houston, TX, USA.
Tariq CheemaDivision of Pulmonary and Critical Care, Allegheny Health Network, Pittsburgh, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe mortality rate and outcomes of septic shock can vary, depending on the patient's race. The most comprehensive national study on these racial disparities is dated, and recent studies have reported mixed findings.

objectiveTo gain insight into racial variation in outcomes of septic shock and understand underlying factors.

designA retrospective analysis using National Inpatient Sample data (2016-2020). Patients were grouped by race, and patient and hospital characteristics, outcomes, and complications were compared. Multivariable logistic regression analyses were conducted. PATIENTS: Hospitalized patients aged ≥ 18 years with septic shock. MAIN MEASURES: In-hospital mortality, mechanical ventilation, vasopressor use, acute kidney injury, need for hemodialysis, acute myocardial infarction, requirement for blood transfusion, length of stay, the financial burden on healthcare, and resource utilization. KEY

resultsAmong 2,789,890 patients, 67.5% were White, 14.4% Black, 10.9% Hispanic, 3.3% Asian or Pacific Islander, and 0.8% Native American; 46.2% were aged > 70 years. Compared to White patients, Black patients had 23% higher odds of mortality (adjusted odds ratio [aOR] 1.23, 95% CI 1.21-1.25) and the highest odds of invasive mechanical ventilation (aOR 1.42) and hemodialysis (aOR 1.96). Native American patients had the highest odds of acute respiratory distress syndrome (aOR 2.03), while Asian or Pacific Islander patients had increased odds of blood transfusions (aOR 1.52). Palliative care consultations were less common among Asian, Black, and Hispanic patients compared to White patients.

conclusionsRacial disparities persist in septic shock outcomes, with higher mortality and complications among Black, Hispanic, Asian, and Native American patients, along with less utilization of palliative care services compared to White patients.

Indexed as

Healthcare DisparitiesHealth Status DisparitiesRacial GroupsShock, SepticAdultAgedAged, 80 and overFemaleHospital MortalityHumansMaleMiddle AgedRetrospective StudiesUnited StatesHealthcare outcomesIn-hospital mortalityMechanical ventilationNational Inpatient SampleRacial disparitiesSeptic shock

Identifiers

PMID40229604
PMCPMC12612496

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