ArticleNature genetics2025
Wheat tandem kinase RWT4 directly binds a fungal effector to activate defense.
Article in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Gb3 encodes a unique kinase fusion protein conferring greenbug resistance in wheat.Nature genetics · 2026Article
- Engineering plant tandem kinase immune receptors expands effector recognition profiles.Science advances · 2026Article
- Mechanisms and balanced regulation of plant immunity.Nature reviews. Molecular cell biology · 2026Review
- Resistance to the oat leaf blotch pathogen (Pyrenophora avenae) is delimited to a region of chromosome 1D that harbors a candidate resistance kinase fusion protein.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- An HMA-like integrated domain in the wheat tandem kinase WTK4 recognises an RNase-like pathogen effector.Nature communications · 2026Article
- The emerging role of kinase fusion proteins in cereal immunity.Nature genetics · 2026Review
- Field pathogenomics and evolutionary conservation unveil CRISPR-targetable susceptibility genes for wheat blast resistance.Scientific reports · 2026Article
- Virulence on Pm4 kinase-based resistance is determined by two divergent wheat powdery mildew effectors.Nature plants · 2026Article
- Orchestration of plant PRR- and NLR-mediated immunity: Protein kinases and beyond.Molecular cell · 2025Review
- Tandem kinase-NLR pairs: Novel paradigms in cereal disease resistance.Plant communications · 2025Article
- Wheat tandem kinase RWT4 directly binds a fungal effector to activate defense.Nature genetics · 2025Article
- Plant Pattern recognition receptors: Exploring their evolution, diversification, and spatiotemporal regulation.Current opinion in plant biology · 2024Article
- Tandem Kinase WTK1 Triggers Waves of Transcriptional Reprogramming Underlying Wheat Resistance to Stripe Rust.Physiologia plantarumArticle
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Authors and funding
8 authors.
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Abstract
Plants have intricate innate immune receptors that detect pathogens. Research has intensely focused on two receptor classes recognizing external and internal threats. Recent research has identified a class of disease-resistance proteins called tandem kinase proteins (TKPs). We investigated RWT4, a wheat TKP that confers resistance to the devastating fungal pathogen Magnaporthe oryzae. We established a rice protoplast system, revealing RWT4 specifically recognizes the AvrPWT4 effector, leading to the transcription of defense genes and inducing cell death. RWT4 possesses both kinase and pseudokinase domains, with its kinase activity essential for defense. RWT4 directly interacts with and transphosphorylates AvrPWT4. Biolayer interferometry revealed both RWT4 kinase and pseudokinase regions bind the effector. Sequence similarity and structural modeling revealed a partial kinase duplication in RWT4's kinase region as critical for effector interaction and defense activation. Collectively, these findings demonstrate that TKPs can directly bind a recognized effector, leading to downstream defense activation.
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