Mesobuthus eupeus venom modulates colorectal carcinoma signaling pathways and induces apoptosis.

Havva Nur Canak, Kemal Bas, Ersen Aydın Yağmur, Serdar Karakurt

Abstract read

In one paragraph

Article in Medical oncology (Northwood, London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Scorpio fuscus venom as a promising anticancer agent against colorectal cancer.Investigational new drugs · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Havva Nur CanakFaculty of Science, Department of Biochemistry, Selcuk University, Konya, Türkiye.ORCID http://orcid.org/0009-0005-4453-6936

Kemal BasFaculty of Science, Department of Biochemistry, Selcuk University, Konya, Türkiye.ORCID http://orcid.org/0000-0003-0881-9793

Ersen Aydın YağmurDepartment of Plant and Animal Production, Alasehir Vocational High School, Manisa Celal Bayar University, Manisa, Türkiye.ORCID http://orcid.org/0000-0002-0396-3975

Serdar KarakurtFaculty of Science, Department of Biochemistry, Selcuk University, Konya, Türkiye. kserdar1@yahoo.com.ORCID http://orcid.org/0000-0002-4449-6103

Funding

Selçuk University Research Foundation 22401106Türkiye Bilimsel ve Teknolojik Araştırma Kurumu 120Z942

6 · The paper itself

Abstract

Colorectal cancer (CRC) is a significant global health concern, often challenging to treat effectively with conventional methods and burdened by adverse effects. Scorpion venoms offer a unique avenue for exploration, given their ability to disrupt the cell cycle, inhibit growth, and trigger apoptosis. This study delves into the impact of Mesobuthus eupeus (M. eupeus) scorpion venom on the proliferation and progression of colorectal cancer at the molecular level. The total protein concentration in the venom (607.5 µg/mL) also emphasized the rich composition and potential for therapeutic applications. The study reveals that M. eupeus venom effectively reduced the proliferation of DLD-1 and HT-29 colorectal cancer cells in a dose-dependent manner with IC

Indexed as

ApoptosisColorectal NeoplasmsScorpion VenomsSignal TransductionAnimalsAnimals, PoisonousCell Line, TumorCell MovementCell ProliferationHT29 CellsHumansScorpionsScorpion VenomsColorectal cancerCytotoxicityMesobuthus eupeusMolecular mechanismVenom

Identifiers

PMID40229568

DOI10.1007/s12032-025-02689-2

PMCPMC11996983

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.